Ameloblastoma (AB), dentigerous cyst (DC) and Odontogenic keratocyst (OKC) are odontogenic lesions with propensity to malignant transformation or local invasion. The molecular mechanisms of development of these lesions are not fully understood. However, some researches have reported dysregulation of tumor suppressor genes or oncogenes in these lesions. Down-regulation of P53 gene has been reported in AB, DC and OKC. Moreover, several long non-coding RNAs such as ENST00000512916 and KIAA0125 have been dysregulated in AB tissues. Single nucleotide polymorphisms within a variety of genes have been associated with certain types of odontogenic lesions. In the current review, we summarize the current data about the expression pattern of genes in these lesions and the observed association between genetic polymorphisms and development of these lesions.

成釉细胞瘤（AB），齿状囊肿（DC）和牙源性角化囊肿（OKC）是牙源性病变，易发生恶性转化或局部浸润。这些病变发展的分子机制尚未完全了解。然而，一些研究报道了这些病变中的抑癌基因或癌基因失调。在AB，DC和OKC中已经报道了P53基因的下调。此外，AB组织中一些长的非编码RNA如ENST00000512916和KIAA0125失调。多种基因中的单核苷酸多态性已经与某些类型的牙源性病变相关。在当前的审查中，我们总结了有关这些病变中基因表达模式的当前数据以及观察到的遗传多态性与这些病变的发展之间的关联。