Abstract Simaroubaceae family belongs to the order Sapindales, which in turn is part of Eurosides II (APG IV). It consists of 23 genera: Ailanthus; Amaroria; Brucea; Castela; Eurycoma; Gymnostemon; Hannoa; Holacantha; Homalolepsis; Iridosma; Laumoniera; Leitneria; Nothospondias; Odyendeya; Perriera; Picrasma; Picrolemma; Pierreodendron; Quassia; Samadera; Simaba; Simarouba; Soulamea. Over the years, the classification of Simaroubaceae has changed and there is still a lot to evolve in this direction since there are still not many studies on some of its genera. In this sense, the present work discusses the chemistry of Simaroubaceae through the micromolecular chemical data, evolutionary indexes and chemometric analysis in order to assess affinities between its genera. The chemistry of this family is diverse and includes quassinoids, alkaloids, triterpenes, flavonoids, simple phenolics, coumarins, lignans and quinones. In addition to presenting specificity, quassinoids and alkaloids are prevalent among the substances already identified in the family and can be considered the chemical markers of it. Quassionoids are degraded triterpenes and can be classified as c25, c22, c20, c 19 and c18; c20 being the most common type in the family. The alkaloids already isolated in Simaroubaceae are predominantly beta-carboline and canthinone, both originating from the amino acid tryptophan. The evolutionary indexes calculated for the chemical markers showed great variation between the genera of Simaroubaceae and showed no correlation among them. The chemometric analysis positioned Simaroubaceae close to Rutaceae within the order Sapindales and, among the genera, alkaloids and quassinoids were very important for their distribution in Simaroubaceae considering the evolutionary proximity, corroborating their selection as chemical markers.

中文翻译：

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化学计量学分析应用于 Simaroubaceae 科的化学现象学方法：生物碱和类黄酮的相关性

摘要 Simaroubaceae 家庭属于无患子目，而无患子目又是 Eurosides II (APG IV) 的一部分。它由 23 个属组成：臭椿；阿玛罗里亚；布鲁西亚; 卡斯特拉; 肉瘤; Gymnostemon; 汉诺亚; 荷拉坎塔; 失常症；虹膜; 劳莫涅拉；莱特纳里亚；诺斯波迪亚斯；奥登德亚；佩里埃拉；皮克拉玛; 苦苣苔; 杜鹃花; 苦木; 萨马德拉；司马巴; 西马鲁巴；苏拉米亚。多年来，苦木科的分类发生了变化，由于对其某些属的研究仍然不多，因此在这个方向上仍有很多发展空间。从这个意义上说，目前的工作通过小分子化学数据、进化指数和化学计量分析讨论了 Simaroubaceae 的化学，以评估其属之间的亲和力。该家族的化学成分多种多样，包括类黄酮、生物碱、三萜、类黄酮、简单酚类、香豆素、木脂素和醌。除了表现出特异性外，类成分和生物碱在该家族中已经确定的物质中普遍存在，可以被认为是其化学标志物。Quassionoids 是降解的三萜类化合物，可分为 c25、c22、c20、c 19 和 c18；c20 是家族中最常见的类型。已经在 Simaroubaceae 中分离的生物碱主要是 β-咔啉和角豆酮，两者都来自氨基酸色氨酸。化学标记计算的进化指标表明，苦木科各属间变异较大，无相关性。化学计量学分析将 Simaroubaceae 与芸香科定位在无患子目内，并且在属中，