Abstract

Novel shell crosslinked (SCL) pH- and reduction-responsive micelles were fabricated through the grafting of DMAEMA and AA monomers onto a star-shaped PCL through ATRP followed by crosslinking with Cys. The chemical structures of the samples were investigated using ¹H NMR and FTIR. The developed micelles were loaded with MTX as an anticancer drug and their drug loading and encapsulation efficiencies were calculated to be 31.53 ± 0.3% for both. The fabricated drug delivery system (DDS) exhibited slow and stimuli-triggered drug release behavior. The anticancer performance of the DDS was examined using MTT assay against MCF7 cells.

中文翻译：

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来自星形三元共聚物的生物还原性和pH响应性壳交联聚合物胶束作为药物输送系统

摘要

通过将DMAEMA和AA单体通过ATRP接枝到星形PCL上，然后与Cys交联，制备了新型的壳交联（SCL）pH和还原反应性胶束。使用¹ H NMR和FTIR研究了样品的化学结构。用MTX作为抗癌药加载已开发的胶束，两者的载药量和包封效率经计算均为31.53±0.3％。预制的药物输送系统（DDS）表现出缓慢且受刺激触发的药物释放行为。使用MTT分析针对MCF7细胞检查了DDS的抗癌性能。