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HDAC2 promotes the EMT of colorectal cancer cells and via the modular scaffold function of ENSG00000274093.1
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2020-12-15 , DOI: 10.1111/jcmm.16186
Zhi-Peng Qi 1, 2 , Ayimukedisi Yalikong 1, 2 , Jia-Wei Zhang 3 , Shi-Lun Cai 1, 2 , Bing Li 1, 2 , Sun Di 1, 2 , Zhen-Tao Lv 1, 2 , En-Pan Xu 1, 2 , Yun-Shi Zhong 1, 2 , Ping-Hong Zhou 1, 2
Affiliation  

Histone deacetylase 2 (HDAC2), a member of the Histone deacetylase family, plays a vital role in various carcinomas. In this study, we identified that HDAC2 expression levels are associated with liver metastasis, higher T stages and poor prognosis in colorectal cancer. HDAC2 down‐regulation via lentivirus‐mediated expression of HDAC2‐targeting shRNA reduced the in vitro migration and invasion ability of HCT116 cell as well as their liver metastasis in nude mouse xenografts. Mechanistically, HDAC2 promotes epithelial‐mesenchymal transition (EMT) in colorectal cancer cells by combining HDAC1 with EZH2 (a key histone methyltransferase), possibly through the modular scaffold function of a new lncRNA, ENSG00000274093.1. HDAC2 thus appears to promote CRC cell migration and invasion through binding HDAC1 and EZH2 via ENSG00000274093.1.

中文翻译:

HDAC2通过ENSG00000274093.1的模块化支架功能促进结直肠癌细胞的EMT

组蛋白去乙酰化酶 2 (HDAC2) 是组蛋白去乙酰化酶家族的成员,在各种癌症中起着至关重要的作用。在这项研究中,我们发现 HDAC2 表达水平与结直肠癌的肝转移、较高的 T 分期和不良预后相关。通过慢病毒介导的 HDAC2 靶向 shRNA 表达下调 HDAC2 降低了 HCT116 细胞的体外迁移和侵袭能力以及它们在裸鼠异种移植物中的肝转移。从机制上讲,HDAC2 通过将 HDAC1 与 EZH2(一种关键的组蛋白甲基转移酶)结合来促进结直肠癌细胞中的上皮间质转化(EMT),可能是通过一种新的 lncRNA 的模块化支架功能,ENSG00000274093.1。因此,HDAC2 似乎通过 ENSG00000274093.1 结合 HDAC1 和 EZH2 来促进 CRC 细胞迁移和侵袭。
更新日期:2021-01-19
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