This systematic review aimed to assess variations in the clinical presentation and treatment outcomes of patients with polycystic ovary syndrome (PCOS) belonging to different ethnicities. A search was performed for studies comparing various clinical aspects of PCOS in two or more different ethnic groups. After screening 2264 studies, 35 articles were included in the final analysis. In comparison with White women with PCOS (wPCOS), East Asian women with PCOS (eaPCOS) were less hirsute, whereas Hispanic women with PCOS (hPCOS), South Asian women with PCOS (saPCOS) and Middle Eastern women with PCOS (mePCOS) were more hirsute. saPCOS had higher androgen and lower sex hormone-binding globulin (SHBG) concentrations, mePCOS had higher DHEAS concentrations, and hPCOS and Black women with PCOS (bPCOS) had lower SHBG and DHEAS measures than wPCOS. Menstrual disturbances were more frequent in eaPCOS. Both saPCOS and eaPCOS had lower body mass index with increased central adiposity. hPCOS and bPCOS were more obese. saPCOS, mePCOS, hPCOS and bPCOS had a higher prevalence of insulin resistance than wPCOS. bPCOS had a better lipid profile but higher blood pressure and cardiovascular risk. Indigenous Australian women with PCOS were more obese and more insulin resistant with higher androgen concentrations. The clinical phenotype of PCOS therefore shows a wide variation depending on ethnicity.

本系统评价旨在评估属于不同种族的多囊卵巢综合征 (PCOS) 患者的临床表现和治疗结果的差异。对比较两个或多个不同种族的 PCOS 不同临床方面的研究进行了搜索。筛选2264篇研究，最终纳入35篇。与患有 PCOS 的白人女性 (wPCOS) 相比，患有 PCOS 的东亚女性 (eaPCOS) 的毛发较少，而患有 PCOS 的西班牙裔女性 (hPCOS)、患有 PCOS 的南亚女性 (saPCOS) 和患有 PCOS 的中东女性 (mePCOS) 的毛发较少多毛。saPCOS 具有较高的雄激素和较低的性激素结合球蛋白 (SHBG) 浓度，mePCOS 具有较高的 DHEAS 浓度，而 hPCOS 和患有 PCOS 的黑人女性 (bPCOS) 的 SHBG 和 DHEAS 测量值低于 wPCOS。eaPCOS 患者的月经紊乱更为频繁。saPCOS 和 eaPCOS 均具有较低的体重指数和增加的中心性肥胖。hPCOS 和 bPCOS 更肥胖。saPCOS、mePCOS、hPCOS 和 bPCOS 的胰岛素抵抗患病率高于 wPCOS。bPCOS 的血脂状况更好，但血压和心血管风险更高。患有多囊卵巢综合征的澳大利亚土著女性更肥胖，胰岛素抵抗程度更高，雄激素浓度更高。因此，PCOS 的临床表型因种族而异。bPCOS 的血脂状况更好，但血压和心血管风险更高。患有多囊卵巢综合征的澳大利亚土著女性更肥胖，胰岛素抵抗程度更高，雄激素浓度更高。因此，PCOS 的临床表型因种族而异。bPCOS 的血脂状况更好，但血压和心血管风险更高。患有多囊卵巢综合征的澳大利亚土著女性更肥胖，胰岛素抵抗程度更高，雄激素浓度更高。因此，PCOS 的临床表型因种族而异。