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What makes the cell cycle tick? a celebration of the awesome power of biochemistry and the frog egg
Molecular Biology of the Cell ( IF 3.3 ) Pub Date : 2020-12-15 , DOI: 10.1091/mbc.e20-10-0626
Marc Kirschner 1
Affiliation  

The cell cycle, a 19th century discovery of cytologists, only achieved a satisfactory biochemical explanation in the last 20 years of the 20th century. This personal retrospective focuses on how biochemical studies of the frog egg helped identify the cyclin-based mitotic oscillator and how this approach quickly merged with genetic studies in yeast to establish the basic mechanism of the eukaryotic cell division cycle. The key feature that made this a cyclic process was regulated protein degradation, mediated by ubiquitin, catalyzed by a massive enzyme machine, called the Anaphase Promoting Complex.



中文翻译:

是什么让细胞周期滴答作响?庆祝生物化学和青蛙蛋的惊人力量

细胞周期是19世纪细胞学家的发现,直到20世纪最后20年才取得了令人满意的生化解释。这个个人回顾重点关注青蛙卵的生化研究如何帮助识别基于细胞周期蛋白的有丝分裂振荡器,以及这种方法如何快速与酵母中的遗传研究相结合,以建立真核细胞分裂周期的基本机制。使其成为循环过程的关键特征是受调节的蛋白质降解,由泛素介导,由称为后期促进复合物的大型酶机器催化。

更新日期:2020-12-16
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