Hospital acquired infections (HAI) are the most common complication found in the hospital environment. The aim of the study was to examine whether the use of an antimicrobial coating in high-touch areas in an orthopedic ward could reduce bacterial growth and HAI. From December 2017 to February 2018, HAI were registered on two orthopedic wards. A second registration was performed from December 2018 to February 2019. On the second occasion, an antimicrobial organosilane coating was applied just before the study period and thereafter weekly on one ward, while the other ward served as a control. Twenty defined high-touch areas on each ward were cultured before treatment and after 1, 2, 4, 8, 12, 14 and 16 weeks. Samples were cultured for aerobic colony counts, Staphylococcus aureus and E. coli. The total aerobic colony counts were 47% lower on the treated ward compared with the non-treated ward over the study period (p = 0.02). The colony counts for Staphylococcus aureus and E. coli were low on both wards. During the first registration period, the incidence of HAI was 22.7% and 20.0% on the non-treated and subsequently treated ward respectively. On the second occasion, after treatment, the incidence was 25.0% and 12.5% (treated ward) respectively (p = 0.0001). The use of a long-lasting antimicrobial organosilane coating appears to reduce the bioburden and reduce HAI. Since the incidence of HAI varies substantially over time, longer observation times are needed.

中文翻译：

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在整形外科病房环境中，高接触区域的抗菌涂层与明显降低的好氧菌落数量有关

医院获得性感染（HAI）是在医院环境中发现的最常见的并发症。该研究的目的是检查在骨科病房高接触区域使用抗菌涂层是否可以减少细菌生长和HAI。从2017年12月到2018年2月，HAI在两个骨科病房进行了注册。从2018年12月至2019年2月进行了第二次注册。第二次，在研究期之前和之后每周在一个病房中涂一次抗菌有机硅烷涂层，而另一个病房作为对照。在治疗前和1、2、4、8、12、14和16周后，在每个病房培养20个高触感区域。培养样品的需氧菌落数，金黄色葡萄球菌和大肠杆菌。在研究期间，与未治疗病房相比，治疗病房的总有氧菌落计数降低了47％（p = 0.02）。在两个病房中，金黄色葡萄球菌和大肠杆菌的菌落数均较低。在第一个注册期间，未治疗病房和随后治疗病房的HAI发生率分别为22.7％和20.0％。第二次治疗后，发生率分别为25.0％和12.5％（治疗病房）（p = 0.0001）。使用持久的抗菌有机硅烷涂层似乎可以减少生物负担并减少HAI。由于HAI的发生率随时间变化很大，因此需要更长的观察时间。在第一个注册期间，未治疗病房和随后治疗病房的HAI发生率分别为22.7％和20.0％。第二次治疗后，发生率分别为25.0％和12.5％（治疗病房）（p = 0.0001）。使用持久的抗菌有机硅烷涂层似乎可以减少生物负担并减少HAI。由于HAI的发生率随时间变化很大，因此需要更长的观察时间。在第一个注册期间，未治疗病房和随后治疗病房的HAI发生率分别为22.7％和20.0％。第二次治疗后，发生率分别为25.0％和12.5％（治疗病房）（p = 0.0001）。使用持久的抗菌有机硅烷涂层似乎可以减少生物负担并减少HAI。由于HAI的发生率随时间变化很大，因此需要更长的观察时间。