Objective: To investigate the feasibility of using a wireless wearable device (WD) in differentiated thyroid cancer (DTC) patients undergoing radionuclide therapy with I-131 (RAI) and protected hospitalization, this study compared the measurements of residual radioactivity obtained with those registered by a permanent environmental home device (HD). Methods: Twenty consecutive patients undergoing RAI hospitalized in restricted, controlled areas were enrolled. The patients underwent comprehensive monitoring of vital/nonvital parameters. We obtained 45580± 13 measurements from the WD, detecting the residual radioactivity for each patient during approximately 56 hours of hospitalization, collecting data 53 times per hour. The samples, collected during daily activities, were averaged every two hours, and the results correlated with those from the HD. Bland-Altman analysis was also used to evaluate the agreement between the two techniques. Results: A significant relationship between the WD and HD was observed (r = 0.96, p < 0.0001). Bland-Altman analysis recognized the agreement between measurements by the WD and HD. The mean value at the end of the first day of hospitalization was 80.81 microSv/h and 60.77 microSv/h (p = ns for WD and HD), whereas those at the end of the second day were 47.08 and 24.96 (p = ns). In the generalized linear model (GLM), a similar trend in performance across time was found with the two techniques. Conclusion: This study demonstrates good agreement between the residual radioactivity measures estimated by the WD and HD modalities, rendering them interchangeable. This approach will allow both the optimization of medical staff exposure and safer patient discharge. Abbreviations: wireless device (WD); differentiated thyroid cancer (DTC); radionuclide therapy with I-131 (RAI); home device (HD); generalized linear model (GLM).

中文翻译：

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通过综合无线可穿戴设备评估接受放射性核素治疗的甲状腺癌患者的残余放射性，并与家用设备的结果进行比较：可行性研究

目的：为了研究在接受 I-131 (RAI) 放射性核素治疗和保护性住院治疗的分化型甲状腺癌 (DTC) 患者中使用无线可穿戴设备 (WD) 的可行性，本研究将获得的残余放射性测量值与注册的那些测量值进行比较。永久性环保家用设备 (HD)。方法：纳入了 20 名在限制、控制区域住院的连续 RAI 患者。患者接受了生命/非生命参数的全面监测。我们从 WD 获得了 45580±13 次测量，检测了每位患者在住院约 56 小时内的残留放射性，每小时收集数据 53 次。在日常活动中收集的样本每两小时平均一次，结果与 HD 的结果相关。Bland-Altman 分析也用于评估两种技术之间的一致性。结果：观察到 WD 和 HD 之间存在显着关系（r = 0.96，p < 0.0001）。Bland-Altman 分析确认了 WD 和 HD 测量值之间的一致性。住院第一天结束时的平均值为 80.81 microSv/h 和 60.77 microSv/h（WD 和 HD 的 p = ns），而第二天结束时的平均值为 47.08 和 24.96（p = ns） . 在广义线性模型 (GLM) 中，两种技术都发现了随时间变化的类似性能趋势。结论：这项研究表明，WD 和 HD 模式估计的残余放射性测量值之间具有良好的一致性，使它们可以互换。这种方法将允许优化医务人员暴露和更安全的患者出院。缩写：无线设备（WD）；分化型甲状腺癌（DTC）；用 I-131 (RAI) 进行放射性核素治疗；家用设备（高清）；广义线性模型 (GLM)。