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Chandipura Virus’ Oncolytic Potential in Experimentally Induced Tumor in Mice
Intervirology ( IF 4.6 ) Pub Date : 2020-12-15 , DOI: 10.1159/000512299
Anukumar Balakrishnan , Nikita Malik

Chandipura virus (CHPV) is a tropical pathogen, suggesting its involvement in childhood encephalitis syndrome in India. No reports are available in adult human beings for its pathogenicity. Similarly, in adult mice, the virus does not develop pathogenesis by parenteral route except for intracranial route of infection. The virus is remarkably nonpathogenic to adult immunocompromised nude mice. In vitro in tissue culture, the CHPV infects and kills many types of cells. All of these properties could qualify the CHPV to be a candidate virus for tumor therapy. To prove this, an experimentally induced tumor in a mouse was infected with live CHPV. The results showed that intra-tumoral injection reduced the volume of tumor and increased the longevity of the mice. The study concludes that the CHPV may be a safe tumor therapy virus. More precisely, the discovery of CHPV protein with oncolytic potential may lead to the development of novel drugs/therapeutics.
Intervirology


中文翻译:

Chandipura病毒在小鼠实验性诱导肿瘤中的溶瘤潜能

昌迪普拉病毒(CHPV)是一种热带病原体,表明它参与了印度的儿童脑炎综合征。没有关于成年人类致病性的报道。同样,在成年小鼠中,除颅内感染途径外,该病毒不会通过肠胃外途径发展发病机制。该病毒对成年免疫受损的裸鼠非致病性。在体外组织培养中,CHPV感染并杀死许多类型的细胞。所有这些特性可以使CHPV成为肿瘤治疗的候选病毒。为了证明这一点,将小鼠实验性诱导的肿瘤感染了活的CHPV。结果表明,肿瘤内注射减少了肿瘤的体积并增加了小鼠的寿命。研究得出结论,CHPV可能是一种安全的肿瘤治疗病毒。更确切地说,
病毒学
更新日期:2020-12-15
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