BACKGROUND Intracerebral hemorrhage (ICH) is 7- to 10-fold higher in anticoagulated patients. Given the more extended use of oral anticoagulants, an increase in the prevalence of ICH associated with oral anticoagulation (ICH-OAC) could be expected. However, there is no previous study that assesses the time trends of ICH-OAC in Spain. METHODS We conducted a combined data analysis after creating a joint database of the 3 most important epidemiological studies on ICH-OAC of our country: the EPICES study (2008-2009), the TAC Registry (TR) study (2012-2013) and the TAC Registry 2 (TR2) study (2015). We finally included 65, 235, and 366 patients from the EPICES, TR, and TR2 studies, respectively. RESULTS We have observed a 3.73-fold increase in the crude annual incidence of ICH-OAC throughout the period of study, with proportion of ICH-OAC out of total ICH increasing from 8.4% in 2008 to 18.2% in 2015. Age, dyslipidemia, and prior antiplatelet treatment increased during the study, but we found no statistically significant differences in other risk factors for ICH-OAC. CONCLUSIONS The incidence of ICH-OAC is increasing in our country. It might at least be partly explained by aging of the population, with mean age at presentation being higher in the last years.

中文翻译：

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西班牙2008-2015年口服抗凝治疗相关脑出血时间趋势及其危险因素

背景 在抗凝治疗的患者中，脑出血 (ICH) 的发生率高出 7 至 10 倍。鉴于口服抗凝剂的更广泛使用，可以预期与口服抗凝剂 (ICH-OAC) 相关的 ICH 患病率会增加。然而，之前没有研究评估西班牙 ICH-OAC 的时间趋势。方法 我们在创建了我国 3 项最重要的 ICH-OAC 流行病学研究的联合数据库后进行了联合数据分析：EPICES 研究（2008-2009）、TAC Registry（TR）研究（2012-2013）和TAC Registry 2 (TR2) 研究（2015 年）。我们最终分别纳入了来自 EPICES、TR 和 TR2 研究的 65、235 和 366 名患者。结果 在整个研究期间，我们观察到 ICH-OAC 的粗年发病率增加了 3.73 倍，ICH-OAC 占总 ICH 的比例从 2008 年的 8.4% 增加到 2015 年的 18.2%。 研究期间年龄、血脂异常和既往抗血小板治疗增加，但我们发现 ICH-OAC 的其他危险因素没有统计学显着差异. 结论我国ICH-OAC的发病率呈上升趋势。至少部分原因可能是人口老龄化，过去几年出现的平均年龄更高。