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Association between symptoms of psychological distress and cognitive functioning among adults with coronary artery disease
Stress & Health ( IF 4.1 ) Pub Date : 2020-12-14 , DOI: 10.1002/smi.3018
Kasra Moazzami 1, 2 , Mariana Garcia 1, 2 , An Young 1, 2 , Zakaria Almuwaqqat 1, 2 , Bruno B Lima 1, 2 , Afif Martini 1 , Mhmtjamil Alkhalaf 1 , Amit J Shah 1, 2, 3 , Felicia C Goldstein 4, 5 , Ihab Hajjar 4, 5, 6 , Allan I Levey 4, 5 , J Douglas Bremner 3, 7, 8 , Arshed A Quyyumi 2 , Viola Vaccarino 1, 2
Affiliation  

Greater psychological distress is associated with cognitive impairment in healthy adults. Whether such associations also exist in patients with coronary artery disease (CAD) is uncertain. We assessed cognitive function in 496 individuals with CAD using the verbal and visual memory subtests of the Wechsler Memory Scale and executive functioning measured by the Trail Making Test Parts A and B. We used a composite score of psychological distress derived through summation of Z-transformed psychological distress symptom scales (depression, posttraumatic stress, anxiety, anger, hostility and perceived stress) and scores for each individual psychological scale. Multivariable linear regression models were used to determine the association between memory scores (as outcomes) and the psychological distress scores (both composite score and individual scales). After adjusting for demographic and cardiovascular risk factors, a higher psychological distress score was independently associated with worse memory and executive functioning. Each standard deviation increase in psychological distress score was associated with 3% (95% confidence interval [CI], 1%–5%) to 5% (95% CI, 3–7%) worse cognitive performance (higher Trail A and Trail B, and lower verbal and visual memory scores). Among individuals with CAD, a higher level of psychological distress is independently associated with worse cognitive performance. These findings suggest that psychological risk factors play a role in cognitive trajectories of persons with CAD.

中文翻译:

成年冠心病患者心理困扰症状与认知功能的相关性

更大的心理困扰与健康成年人的认知障碍有关。这种关联是否也存在于冠状动脉疾病 (CAD) 患者中尚不确定。我们使用 Wechsler 记忆量表的语言和视觉记忆子测试以及 Trail Making 测试部分 A 和 B 测量的执行功能评估了 496 名 CAD 患者的认知功能。心理困扰症状量表(抑郁、创伤后压力、焦虑、愤怒、敌意和感知压力)以及每个心理量表的分数。多变量线性回归模型用于确定记忆评分(作为结果)与心理困扰评分(综合评分和个体量表)之间的关联。在调整人口统计学和心血管危险因素后,较高的心理困扰评分与较差的记忆力和执行功能独立相关。心理困扰评分的每个标准差增加都与 3%(95% 置信区间 [CI],1%–5%)至 5%(95% CI,3–7%)的认知表现较差(更高的 Trail A 和 Trail A 和 Trail A)相关B,以及较低的语言和视觉记忆分数)。在 CAD 患者中,较高水平的心理困扰与较差的认知表现独立相关。这些发现表明,心理风险因素在 CAD 患者的认知轨迹中发挥作用。心理困扰评分的每个标准差增加都与 3%(95% 置信区间 [CI],1%–5%)至 5%(95% CI,3–7%)的认知表现较差(更高的 Trail A 和 Trail A 和 Trail A)相关B,以及较低的语言和视觉记忆分数)。在 CAD 患者中,较高水平的心理困扰与较差的认知表现独立相关。这些发现表明,心理风险因素在 CAD 患者的认知轨迹中发挥作用。心理困扰评分的每个标准差增加都与 3%(95% 置信区间 [CI],1%–5%)至 5%(95% CI,3–7%)的认知表现较差(更高的 Trail A 和 Trail A 和 Trail A)相关B,以及较低的语言和视觉记忆分数)。在 CAD 患者中,较高水平的心理困扰与较差的认知表现独立相关。这些发现表明,心理风险因素在 CAD 患者的认知轨迹中发挥作用。
更新日期:2020-12-14
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