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Short Communication: Acquisition of Additional Nuclear Factor Kappa B Binding Sites in Long Terminal Repeat of Genetically Evolving HIV-1 Subtype C Viral Species in Host with Comorbidities
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2021-04-29 , DOI: 10.1089/aid.2020.0195
Gurleen Mehta 1 , Aman Sharma 2 , Sunil K Arora 1
Affiliation  

HIV-1 causes millions of deaths around the world. Higher disease progression and mortality are seen in HIV positive individuals with comorbidities. Two of the most pertinent conditions are coinfection with Mycobacterium tuberculosis and Intravenous Drug abuse. The mechanisms involved, however, still remain unresolved. To elucidate the mechanisms involved, we evaluated the genetic alterations in terms of additional nuclear factor kappa B (NF-κB) sites in the long terminal repeat (LTR) of HIV-1 subtype-C isolates from infected human individuals from North India, supposedly acquired by the emerging viral quasi-species in the infected host in presence of these two comorbid conditions. Interestingly the results indicate higher number of NF-κB sites in the viral isolates from HIV-tuberculosis coinfected (n = 26, 16 isolates with 3 sites and 10 isolates with 2 sites) and intravenous drug users (n = 20, 13 isolates with 3 sites and 7 isolates with 2 sites) compared to the mono-infected hosts (n = 30, 10 isolates with 3 sites, 18 isolates with 2 sites, 2 isolates with 1 site). The biological relevance of these alterations in the NF-κB sites within the HIV-1 LTR with respect to viral replicative capacity and HIV disease progression needs to be studied further.

中文翻译:

简短交流:在患有合并症的宿主中遗传进化的 HIV-1 亚型 C 病毒种的长末端重复序列中获得额外的核因子 Kappa B 结合位点

HIV-1 导致全球数百万人死亡。在有合并症的 HIV 阳性个体中可以看到更高的疾病进展和死亡率。两个最相关的情况是合并感染结核分枝杆菌和静脉药物滥用。然而,所涉及的机制仍未得到解决。为了阐明所涉及的机制,我们评估了来自印度北部受感染人类个体的 HIV-1 亚型 C 分离株的长末端重复序列 (LTR) 中额外核因子 kappa B (NF-κB) 位点的遗传改变,推测在存在这两种合并症的情况下,由受感染宿主中新出现的病毒准种获得。有趣的是,结果表明,在 HIV-结核共感染的病毒分离株中,NF-κB 位点数量更多。n  = 26, 16 株具有 3 个部位,10 株具有 2 个部位)和静脉吸毒者(n  = 20,13 株具有 3 个部位,7 株具有 2 个部位)与单一感染宿主(n  = 30、10 3 个位点的分离株,2 个位点的 18 个分离株,1 个位点的 2 个分离株)。HIV-1 LTR 内 NF-κB 位点的这些改变与病毒复制能力和 HIV 疾病进展的生物学相关性需要进一步研究。
更新日期:2021-05-06
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