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A genetic perspective on the association between exercise and mental health in the era of genome-wide association studies
Mental Health and Physical Activity ( IF 5.957 ) Pub Date : 2020-12-14 , DOI: 10.1016/j.mhpa.2020.100378
Eco J.C. de Geus

Regular exercise is associated with mental health throughout the life course but the chain-of-causality underlying this association remains contested. I review results from genetically informative designs that examine causality, including the discordant monozygotic twin design, multivariate genetic models, Mendelian Randomization, and stratification on polygenic risk scores. Triangulation across the results from these and the standard designs for causal inference (RCT, prospective studies) in the extant literature supports the existence of causal effects of exercise on mental health as well as residual confounding by genetic factors that independently influence participation in regular exercise and mental health outcomes. I present an update of our earlier model for the genetic determinants of voluntary exercise behaviour. The model allows causal effects of regular exercise on mental health to co-exist with genetic pleiotropy through differences in the genetic sensitivity to the mental health benefits of exercise. The model encourages research on strategies that use genomic information to improve the success of interventions on regular exercise behaviour.



中文翻译:

全基因组关联研究时代运动与心理健康之间关联的遗传学观点

在整个生命过程中,定期锻炼与心理健康有关,但是这种联系所基于的因果关系仍然存在争议。我回顾了检查因果关系的遗传信息设计的结果,包括不一致的单卵双胞胎设计,多元遗传模型,孟德尔随机化和多基因风险评分分层。这些结果和因果推理的标准设计(RCT,前瞻性研究)的现有结果中的三角剖分结果表明,运动对心理健康具有因果关系,并且存在遗传因素造成的残余混淆,这些因素会独立影响参加常规运动和心理健康结果。我介绍了我们早期模型中有关自愿运动行为的遗传决定因素的更新。该模型通过对锻炼对心理健康益处的遗传敏感性差异,使经常锻炼对心理健康的因果效应与遗传多效性并存。该模型鼓励对使用基因组信息来提高常规运动行为干预措施成功率的策略进行研究。

更新日期:2021-01-22
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