Background

This study was designed to evaluate the serum malondialdehyde (MDA), non-enzymatic antioxidants (vitamin A and C), macro-minerals (magnesium and calcium), and trace elements (zinc, copper, and iron) levels in patients with coronary artery disease (CAD) and to explore their role in disease progression.

Methods

This prospective case-control study was comprised of 40 CAD patients and 40 healthy volunteers as cases and control subjects, respectively. The level of lipid peroxidation was assessed by measuring the serum MDA level using a UV spectrophotometer. The levels of vitamins A and C were determined by high-performance liquid chromatography (HPLC) and UV spectrophotometric method, respectively. Atomic absorption spectroscopy (AAS) was used to measure serum macro-minerals (Mg and Ca) and trace elements (Zn, Cu, and Fe) concentrations.

Results

The mean age of CAD patients and control subjects was 53.90 ± 2.22 and 37.03 ± 1.50 years, respectively. This study revealed significantly higher concentrations of MDA (p < 0.01) and lower concentrations of vitamin A (p < 0.01), and vitamin C (p < 0.05) in the CAD patients than in control subjects. The mean values of Mg, Cu, Zn, Ca, and Fe were 11.67 ± 0.64, 1.17 ± 0.03, 0.43 ± 0.02, 107.38 ± 1.81, and 1.66 ± 0.04 μg/mL, respectively for the CAD patients and 19.38 ± 0.65, 1.07 ± 0.02, 0.87 ± 0.02, 94.29 ± 1.89, and 1.52 ± 0.05 μg/mL, respectively for the controls and the differences were significant (p < 0.05) between the patients and controls.

Conclusion

From these findings, we can suggest that there is a strong association of CAD with an elevated level of MDA, depleted levels of antioxidants, and altered macro-minerals and trace elements concentrations.

中文翻译：

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氧化应激增加和血清常量矿物质和微量元素水平改变与冠状动脉疾病有关

背景

本研究旨在评估冠状动脉患者的血清丙二醛 (MDA)、非酶抗氧化剂（维生素 A 和 C）、常量矿物质（镁和钙）和微量元素（锌、铜和铁）水平。疾病 (CAD) 并探索它们在疾病进展中的作用。

方法

该前瞻性病例对照研究由 40 名 CAD 患者和 40 名健康志愿者分别作为病例和对照受试者组成。通过使用紫外分光光度计测量血清 MDA 水平来评估脂质过氧化水平。维生素 A 和 C 的含量分别通过高效液相色谱 (HPLC) 和紫外分光光度法测定。原子吸收光谱 (AAS) 用于测量血清中大量矿物质（Mg 和 Ca）和微量元素（Zn、Cu 和 Fe）的浓度。

结果

CAD 患者和对照受试者的平均年龄分别为 53.90 ± 2.22 和 37.03 ± 1.50 岁。该研究显示，与对照组相比，CAD 患者的 MDA 浓度显着更高 ( p < 0.01)，而维生素 A ( p < 0.01) 和维生素 C ( p < 0.05)浓度更低。对于 CAD 患者，Mg、Cu、Zn、Ca 和 Fe 的平均值分别为 11.67 ± 0.64、1.17 ± 0.03、0.43 ± 0.02、107.38 ± 1.81 和 1.66 ± 0.04 μg/mL，分别为 10.68 ± 19.68对照分别为 ± 0.02、0.87 ± 0.02、94.29 ± 1.89 和 1.52 ± 0.05 μg/mL，患者和对照之间的差异显着（p < 0.05）。

结论

从这些发现中，我们可以表明 CAD 与 MDA 水平升高、抗氧化剂水平降低以及大量矿物质和微量元素浓度改变有很强的关联。