当前位置: X-MOL 学术Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Modeling human embryo development with embryonic and extra-embryonic stem cells
Developmental Biology ( IF 2.7 ) Pub Date : 2020-12-14 , DOI: 10.1016/j.ydbio.2020.12.010
Bailey A T Weatherbee 1 , Tongtong Cui 2 , Magdalena Zernicka-Goetz 3
Affiliation  

Early human post-implantation development involves extensive growth combined with a series of complex morphogenetic events. The lack of precise spatial and temporal control over these processes leads to pregnancy loss. Given the ethical and technical limitations in studying the natural human embryo, alternative approaches are needed to investigate mechanisms underlying this critical stage of human development. Here, we present an overview of the different stem cells and stem cell-derived models which serve as useful, albeit imperfect, tools in understanding human embryogenesis. Current models include stem cells that represent each of the three earliest lineages: human embryonic stem cells corresponding to the epiblast, hypoblast-like stem cells and trophoblast stem cells. We also review the use of human embryonic stem cells to model complex aspects of epiblast morphogenesis and differentiation. Additionally, we propose that the combination of both embryonic and extra-embryonic stem cells to form three-dimensional embryo models will provide valuable insights into cell-cell chemical and mechanical interactions that are essential for natural embryogenesis.



中文翻译:

用胚胎和胚胎外干细胞模拟人类胚胎发育

早期人类植入后发育涉及广泛的生长以及一系列复杂的形态发生事件。对这些过程缺乏精确的空间和时间控制会导致流产。鉴于研究自然人类胚胎的伦理和技术限制,需要替代方法来研究人类发育这一关键阶段的潜在机制。在这里,我们概述了不同的干细胞和干细胞衍生模型,它们是了解人类胚胎发生的有用工具,尽管不完善。目前的模型包括代表三个最早谱系中的每一个的干细胞:对应于外胚层的人类胚胎干细胞、下胚层样干细胞和滋养层干细胞。我们还审查了使用人类胚胎干细胞模拟外胚层形态发生和分化的复杂方面。此外,我们建议将胚胎和胚胎外干细胞结合形成三维胚胎模型,将为自然胚胎发生必不可少的细胞-细胞化学和机械相互作用提供有价值的见解。

更新日期:2020-12-14
down
wechat
bug