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Returning to kidney development to deliver synthetic kidneys
Developmental Biology ( IF 2.7 ) Pub Date : 2020-12-14 , DOI: 10.1016/j.ydbio.2020.12.009
Melissa H Little 1
Affiliation  

There is no doubt that the development of transplantable synthetic kidneys could improve the outcome for the many millions of people worldwide suffering from chronic kidney disease. Substantial progress has been made in the last 6 years in the generation of kidney tissue from stem cells. However, the limited scale, incomplete cellular complexity and functional immaturity of such structures suggests we are some way from this goal. While developmental biology has successfully guided advances to date, these human kidney models are limited in their capacity for ongoing nephrogenesis and lack corticomedullary definition, a unified vasculature and a coordinated exit path for urinary filtrate. This review will reassess our developmental understanding of how the mammalian embryo manages to create kidneys, how this has informed our progress to date and how both engineering and developmental biology can continue to guide us towards a synthetic kidney.



中文翻译:

恢复肾脏发育以提供合成肾脏

毫无疑问,可移植合成肾脏的发展可以改善全世界数百万患有慢性肾病的人的预后。在过去 6 年中,从干细胞生成肾组织方面取得了实质性进展。然而,这种结构的有限规模、不完整的细胞复杂性和功能不成熟表明我们离这个目标还有一段距离。虽然迄今为止发育生物学已经成功地引导了进展,但这些人类肾脏模型在持续肾形成的能力方面受到限制,并且缺乏皮质髓质定义、统一的脉管系统和尿滤液的协调出口路径。这篇综述将重新评估我们对哺乳动物胚胎如何创造肾脏的发育理解,

更新日期:2020-12-14
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