Triple-negative breast cancer (TNBC) is a type of breast cancer that has a higher risk of distant recurrence and metastasis, leading to a relatively aggressive biological behaviour and poor outcome. So far, the clinical management of TNBC is challenging because of its heterogeneity and paucity of specific targeted therapy. Recently, various studies have identified a lot of differently expressed long non-coding RNAs (lncRNAs) in TNBC. Those lncRNAs have been reported to play important roles in the multistep process of TNBC tumorigenesis. Here, we review the biological characteristics of lncRNAs, and present the current state of knowledge concerning the expression, function and regulation of lncRNAs in TNBC. Accumulating studies explored the potential lncRNAs-based therapeutics in TNBC, including the techniques of genetic modification using antisense oligonucleotides, locked nucleic acid and RNA nanotechnology. In current review, we also discuss the future prospects of studies about lncRNAs in TNBC and development of lncRNA-based strategies for clinical TNBC patients.

中文翻译：

---

三阴性乳腺癌中的长链非编码 RNA 格局

三阴性乳腺癌（TNBC）是一种具有较高远处复发和转移风险的乳腺癌，导致相对侵袭性的生物学行为和较差的预后。迄今为止，由于 TNBC 的异质性和特异性靶向治疗的缺乏，其临床管理具有挑战性。最近，各种研究在 TNBC 中发现了许多不同表达的长链非编码 RNA (lncRNAs)。据报道，这些 lncRNA 在 TNBC 肿瘤发生的多步骤过程中发挥着重要作用。在这里，我们回顾了 lncRNA 的生物学特性，并介绍了有关 lncRNA 在 TNBC 中的表达、功能和调控的知识现状。越来越多的研究探索了 TNBC 中潜在的基于 lncRNA 的疗法，包括使用反义寡核苷酸、锁核酸和RNA纳米技术进行基因改造的技术。在当前的综述中，我们还讨论了 TNBC 中 lncRNA 研究的未来前景以及临床 TNBC 患者基于 lncRNA 的策略的发展。