Abstract Curcumin is a biologically active substance and a natural antioxidant, but it is almost insoluble in water and has low bioavailability. A possible solution to this barrier could be to use solvents that exhibit low toxicity and are biodegradable. Choline chloride-based deep eutectic solvent (DES) can be used as a co-solvent to increase the solubility of curcumin. The objectives of this study are to introduce and prepare DESs, to measure the solubility of curcumin in water and DES as well as in water - DES mixtures with different weight percentages. In this perspective, the solubility of Curcumin is measured in the mixtures of water with some DESs based on choline chloride (ChCl) and in pure solvents at T = 298.15 K to 318.15 K. The measured solubility data were correlated by the activity coefficients models e-NRTL and UNIQUAC. Finally, the apparent thermodynamic functions entropy, enthalpy, and Gibbs free energy were estimated for dissolution using van't Hoff equation.

中文翻译：

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一些基于氯化胆碱的低共熔溶剂溶液作为不同温度下的新型绿色溶剂提高姜黄素的溶解度

摘要 姜黄素是一种生物活性物质和天然抗氧化剂，但几乎不溶于水，生物利用度低。该障碍的一个可能解决方案是使用具有低毒性且可生物降解的溶剂。基于氯化胆碱的低共熔溶剂 (DES) 可用作共溶剂以增加姜黄素的溶解度。本研究的目的是引入和制备 DES，以测量姜黄素在水和 DES 以及不同重量百分比的水 - DES 混合物中的溶解度。从这个角度来看，姜黄素的溶解度是在水与一些基于氯化胆碱 (ChCl) 的 DES 的混合物中以及在 T = 298.15 K 至 318.15 K 的纯溶剂中测量的。测量的溶解度数据通过活性系数模型 e 相关联-NRTL 和 UNIQUAC。最后，