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Real-time in vivo magnetic induction tomography in rabbits: a feasibility study
Measurement Science and Technology ( IF 2.4 ) Pub Date : 2020-12-12 , DOI: 10.1088/1361-6501/abc579
Qihui Chen 1 , Runsheng Liu 2 , Cong Wang 3 , Ruigang Liu 1
Affiliation  

As a noncontact, noninvasive medical imaging technique, magnetic induction tomography (MIT) can measure the conductivity distribution inside the human body. Moreover, animal testing is crucial before performing clinical trials. An abdominal subcutaneous injection rabbit model was used to simulate two local conductivity perturbations, that is, (1) injecting a 0.9% NaCl solution and (2) injecting in vitro heparinized blood. Using an improved MIT data acquisition system to record the data, a series of time-difference reconstructed images were obtained for every 3 ml of injection. The target with an increased conductivity distribution can clearly be observed in the reconstructed images. The maximum target value in all the images increased with the injection dosage. The slopes of the regression line for the mean of the maximum target value in the two groups were statistically different. This preliminary rabbit test shows the feasibility of the in vivo application for MIT and will be the basis for further animal tests.



中文翻译:

体内实时磁感应层析成像:可行性研究

磁感应断层扫描(MIT)作为一种非接触式,无创医学成像技术,可以测量人体内部的电导率分布。此外,在进行临床试验之前,动物测试至关重要。使用腹部皮下注射兔模型模拟两个局部电导率扰动,即(1)注射0.9%NaCl溶液和(2)体外注射肝素化的血液。使用改进的MIT数据采集系统记录数据,每注射3 ml可获得一系列时差重建图像。在重建图像中可以清晰地观察到具有增加的电导率分布的目标。所有图像的最大目标值均随注射剂量的增加而增加。两组最大目标值的平均值的回归线斜率在统计上不同。这项初步的兔子试验证明了麻省理工学院体内应用的可行性,并将成为进一步动物试验的基础。

更新日期:2020-12-12
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