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Effects of menstrual cycle and menopause on internal carotid artery shear-mediated dilation in women
American Journal of Physiology-Heart and Circulatory Physiology ( IF 4.8 ) Pub Date : 2020-12-11 , DOI: 10.1152/ajpheart.00810.2020
Erika Iwamoto 1 , Rintaro Sakamoto 1 , Wakako Tsuchida 2 , Kotomi Yamazaki 1 , Tatsuki Kamoda 1 , Toru Neki 1 , Masaki Katayose 1 , Darren P. Casey 3, 4, 5
Affiliation  

This study aimed to elucidate the effects of change in estrogen during the menstrual cycle and menopause on shear-mediated dilation of the internal carotid artery (ICA), a potential index of cerebrovascular endothelial function. Shear-mediated dilation of the ICA and serum estradiol were measured in 11 premenopausal (Pre-M, 21±1yrs), 13 perimenopausal (Peri-M, 49±2yrs), and 10 postmenopausal (Post-M, 65±7yrs) women. Measurements were made twice within the Pre-M group at their early follicular (EF, lower estradiol) and late follicular (LF, higher estradiol) phases. Shear-mediated dilation was induced by 3min of hypercapnia (target PETCO2 +10mmHg from individual baseline) and was calculated as the percent rise in peak diameter relative to baseline diameter. ICA diameter and blood velocity were simultaneously measured by Doppler ultrasound. In Pre-M, shear-mediated dilation was higher during the LF phase than during the EF phase (P<0.01). Comparing all groups, shear-mediated dilation was reduced across the menopausal transition (P<0.01), and Pre-M during the LF phase showed the highest value (8.9±1.4%) compared with other groups (Pre-M in EF, 6.4±1.1%; Peri-M, 5.5±1.3%; Post-M, 5.2±1.9%, P<0.05 for all). Shear-mediated dilation was positively correlated with serum estradiol even after adjustment of age (P<0.01, r=0.55, age-adjusted; P=0.02, r=0.35). Collectively, these data indicate that controlling the menstrual cycle phase is necessary for the cross-sectional assessments of shear-mediated dilation of the ICA in premenopausal women. Moreover, current findings suggest that a decline in cerebrovascular endothelial function may be partly related to the reduced circulating estrogen levels in peri- and postmenopausal women.

中文翻译:

月经周期和更年期对女性颈内动脉剪切介导的扩张的影响

这项研究旨在阐明月经周期和更年期雌激素的变化对颈动脉内动脉(ICA)的剪切介导扩张的影响,ICA是脑血管内皮功能的潜在指标。测量了11位绝经前(M前,21±1岁),13位围绝经(Peri-M,49±2岁)和10位绝经后(M后,65±7岁)妇女的剪切介导的ICA和血清雌二醇的扩张。在Pre-M组中,在卵泡早期(EF,雌二醇较低)和卵泡晚期(LF,雌二醇较高)阶段进行了两次测量。3分钟的高碳酸血症(目标P ET CO 2(从单个基线开始+ 10mmHg),并计算为峰直径相对于基线直径的上升百分比。通过多普勒超声同时测量ICA直径和血流速度。在Pre-M中,LF阶段的剪切介导的扩张高于EF阶段(P <0.01)。与所有组相比,绝经过渡期剪切介导的扩张减少(P <0.01),而LF期的Pre-M值最高(8.9±1.4%),高于其他组(EF的Pre-M,6.4) ±1.1%; Peri-M,5.5±1.3%; M后,5.2±1.9%,所有P <0.05)。即使在调整年龄后,剪切介导的扩张与血清雌二醇也呈正相关(P <0.01,r = 0.55,经年龄调整; P = 0.02,r = 0.35)。总的来说,这些数据表明,对绝经前女性进行剪切介导的ICA扩张的横断面评估时,必须控制月经周期阶段。此外,目前的发现表明,绝经前后妇女的脑血管内皮功能下降可能部分与循环雌激素水平降低有关。
更新日期:2020-12-12
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