Ghrelin is a regulatory peptide that is the endogenous ligand of the growth hormone secretagogue 1a (GHS-R1a) which belongs to the G protein-coupled receptor family. Ghrelin and GHS-R1a are widely expressed in the central and peripheral tissues and play therapeutic potential roles in the cytoprotection of many internal organs. Endoplasmic reticulum stress (ERS), oxidative stress, and autophagy dysfunction, which are involved in various diseases. In recent years, accumulating evidence has suggested that ghrelin exerts protective effects by regulating ERS, oxidative stress, and autophagy in diverse diseases. This review article summarizes information about the roles of the ghrelin system on ERS, oxidative stress, and autophagy in multiple diseases. It is suggested that ghrelin positively affects the treatment of diseases and may be considered as a therapeutic drug in many illnesses.

中文翻译：

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生长素释放肽对内质网应激、氧化应激和自噬的调节作用：治疗潜力

Ghrelin 是一种调节肽，是属于 G 蛋白偶联受体家族的生长激素促分泌素 1a (GHS-R1a) 的内源性配体。Ghrelin 和 GHS-R1a 在中枢和外周组织中广泛表达，并在许多内脏器官的细胞保护中发挥治疗潜在作用。内质网应激（ERS）、氧化应激和自噬功能障碍，与多种疾病有关。近年来，越来越多的证据表明，ghrelin 通过调节 ERS、氧化应激和自噬在多种疾病中发挥保护作用。这篇综述文章总结了关于 ghrelin 系统在 ERS、氧化应激和自噬在多种疾病中的作用的信息。