Purpose. The prognostic value of a new scoring system, termed F-NLR, that combines pretreatment fibrinogen level with neutrophil-lymphocyte ratio has been evaluated in various cancers. However, the results are controversial. The purpose of this study was to comprehensively analyze the prognostic value of F-NLR score in patients with cancers. Methods. An integrated search of relevant studies was conducted by screening the PubMed and Embase databases. Pooled hazard ratios, with 95% confidence intervals (CIs), for overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS) were calculated to estimate the prognostic significance of F-NLR score in patients with various tumors. A random effects model was used for comprehensive analysis, and subgroup and meta-regression analyses were used to explore sources of heterogeneity. Results. Thirteen articles reporting data from of 4747 patients were included in the study. Pooled analysis revealed that high F-NLR score was significantly associated with poor OS (; 95% CI, 1.51–2.08) and poor DFS/PFS (; 95% CI, 1.30–2.05). Subgroup and meta-regression analyses did not alter the prognostic role of F-NLR score in OS and DFS/PFS. Conclusions. Increased F-NLR score is significantly associated with poor prognosis in patients with cancers and can serve as an effective prognostic indicator.

中文翻译：

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联合预处理纤维蛋白原和中性粒细胞-淋巴细胞比率在各种癌症中的预后意义：系统评价和荟萃分析

目的。一种新的评分系统（称为 F-NLR）的预后价值已在各种癌症中进行了评估，该系统将治疗前纤维蛋白原水平与中性粒细胞 - 淋巴细胞比率相结合。然而，结果是有争议的。本研究旨在综合分析F-NLR评分对癌症患者的预后价值。方法. 通过筛选 PubMed 和 Embase 数据库对相关研究进行综合搜索。计算总生存期 (OS) 和无病生存期 (DFS)/无进展生存期 (PFS) 的合并风险比和 95% 置信区间 (CI)，以估计 F-NLR 评分在患有以下疾病的患者中的预后意义各种肿瘤。综合分析采用随机效应模型，采用亚组和元回归分析探讨异质性来源。结果。该研究纳入了 13 篇报道来自 4747 名患者的数据的文章。汇总分析显示，高 F-NLR 评分与较差的 OS 显着相关（; 95% CI, 1.51–2.08) 和较差的 DFS/PFS (; 95% CI，1.30–2.05）。亚组和元回归分析并未改变 F-NLR 评分在 OS 和 DFS/PFS 中的预后作用。结论。F-NLR 评分增加与癌症患者的不良预后显着相关，可作为有效的预后指标。