This study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl iron (CI) and magnetite Fe₃O₄ nanopowders were embedded as magnetosensitive materials in PDMS resins for the fabrication of macroporous sponges via a sugar-template process. The process is environmentally friendly and simple. The fabricated interconnected macroporous magnetic particles loaded PDMS sponges possess flexible skeletons and good recyclability because of their recoverability after compression (deformation) without any breakdown. The prepared magnetic PDMS sponges were evaluated for their morphology (SEM and EDS), porosity (absorbency), elastic modulus, deformation under a magnetic field, thermostability, and in vitro cell studies. All physicochemical and magnetomechanical analysis confirmed that the optimized magnetic-field-sensitive PDMS sponge can provide an efficient method for delivering an on-demand dose of anticancer drug solutions at a specific location and timing with the aid of controlled magnetic fields.

中文翻译：

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装有抗癌药物5-氟尿嘧啶的可磁场触发的大孔PDMS海绵

这项研究旨在准备，优化和表征磁场敏感的糖模板聚二甲基硅氧烷（PDMS）海绵，用于局部递送抗癌药物5-氟尿嘧啶（FLU）。为此，需要使用不同浓度的羰基铁（CI）和磁铁矿Fe ₃ O ₄将纳米粉末作为磁敏材料嵌入PDMS树脂中，以通过糖模板工艺制造大孔海绵。该过程是环保且简单的。制成的相互连接的大孔磁性粒子填充的PDMS海绵具有柔韧性强的骨架和良好的可回收性，因为它们在压缩（变形）后可恢复，且无任何破裂。对制备的磁性PDMS海绵的形态（SEM和EDS），孔隙率（吸收性），弹性模量，磁场下的变形，热稳定性和体外进行评估。细胞研究。所有的物理化学和磁机械分析都证实，优化的磁场敏感型PDMS海绵可以提供一种有效方法，借助受控磁场在特定位置和时间点按需提供一定剂量的抗癌药溶液。