This study aimed to investigate the association of IgG glycosylation and esophageal precancerosis for squamous cell carcinoma and determine its role in inflammation. Primary glycans selected by the LASSO algorithm were validated using univariate and multivariate logistics models plus restricted cubic spline functions. In total, 24 direct glycans and 27 derived traits were detected, among which 4 glycans and 3 derived traits were primarily selected. Then, GP5 (adjusted OR: 0.805), GP17 (adjusted OR: 1.305), G12n (adjusted OR: 1.271), Gal_1 (adjusted OR: 0.776) and Fuc (adjusted OR: 0.737) were validated and significantly associated with esophageal precancerosis. Additionally, there was a consistent positive association in GP17 and G12n and a negative association in GP5, Gal_1, and Fuc by restricted cubic spline function. Compared with esophageal inflammation, GP17, G12n, and Fuc were still independently associated with precancerosis. In brief, the IgG glycosylation profile was independently associated with esophageal precancerosis beyond inflammation, which could be an early biomarker for esophageal cancer.

中文翻译：

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炎症后 IgG 糖基化与食管癌前病变的关联

本研究旨在探讨 IgG 糖基化与食管癌前病变在鳞状细胞癌中的关系，并确定其在炎症中的作用。使用单变量和多变量物流模型以及受限三次样条函数验证 LASSO 算法选择的初级聚糖。共检测到24个直接聚糖和27个衍生性状，其中初步选择了4个聚糖和3个衍生性状。然后，GP5（校正 OR：0.805）、GP17（校正 OR：1.305）、G12n（校正 OR：1.271）、Gal_1（校正 OR：0.776）和 Fuc（校正 OR：0.737）被验证并与食管癌前病变显着相关。此外，受限三次样条函数在 GP17 和 G12n 中存在一致的正关联，而在 GP5、Gal_1 和 Fuc 中存在一致的负关联。与食管炎症相比，GP17、G12n 和 Fuc 仍与癌前病变独立相关。简而言之，IgG糖基化谱与炎症以外的食管癌前病变独立相关，这可能是食管癌的早期生物标志物。