Commercially available hydroxypropyl methylcellulose capsules are employed as a fast, safe, and user-friendly chemical delivery system containing all reagents (catalyst, ligand, and base) for three important transition-metal-catalyzed reactions: Buchwald–Hartwig, Suzuki–Miyaura, and metallophotoredox C–N cross-coupling reactions. This encapsulation methodology simplifies the screening of reaction conditions and the preparation of compound libraries using parallel synthesis in organic solvents or aqueous media. These reagents-containing HPMC capsules are easy to prepare, come in different sizes, and can be stored on the bench under noninert conditions.

中文翻译：

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试剂和催化剂胶囊：用于化学反应筛选和平行合成的化学传递系统

市场上可买到的羟丙基甲基纤维素胶囊被用作一种快速，安全且用户友好的化学传递系统，其中包含用于三种重要的过渡金属催化反应的所有试剂（催化剂，配体和碱）：Buchwald–Hartwig，Suzuki–Miyaura和金属光氧化还原C–N交叉偶联反应。这种封装方法简化了反应条件的筛选，并通过在有机溶剂或水性介质中的平行合成简化了化合物库的制备。这些包含试剂的HPMC胶囊易于制备，尺寸不同，可以在非惰性条件下存放在工作台上。