The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.

本综述的目的是总结自闭症谱系障碍（ASD）中各种金属微量营养素的异常水平的普遍性，包括铜（Cu），铁（Fe），镁（Mg），锌（Zn）和硒（Se） ）使用头发，指甲和血清样本。还使用基因本体论（GO）术语对选定的异常金属离子与已知的神经发育过程进行了关联。这篇综述中的数据来自全球范围内进行的ASD临床研究。还根据性别（男性/女性）分析和讨论金属离子视差数据，以建立任何性别相关的相关性。最后，提出了一个合理的观点和可能的途径，以更好地理解金属微量营养素在ASD中的作用。