Purpose: To determine whether thermoregulatory capacity is altered by MS during exercise in the heat. Methods: Sixteen MS (EDSS: 2.9±0.9; 47±8 y; 77.6±14.0 kg) and 14 healthy (CON) control participants (43±11 y; 78.6±17.0 kg) cycled at a heat production of 4 W.kg^-1 for 60 minutes at 30˚C, 30%RH (WARM). A subset of 8 MS (EDSS: 2.6±0.5; 44±8 y; 82.3±18.2 kg) and 8 CON (44±12 y; 81.2±21.1 kg) also exercised at 35°C, 30%RH (HOT). Rectal (T_re), mean skin (T_sk) temperature, and local sweat rate on the upper-back (LSR_back) and forearm (LSR_arm), were measured. Results: All CON, yet only 9 of 16, and 7 of 8 MS participants completed 60 min of exercise in WARM and HOT trials, respectively. All MS participants unable to complete exercise stopped with ∆T_re between 0.2-0.5˚C. The time to reach a ∆T_re of 0.2˚C was similar (MS:28±15 min, CON: 32±18 min; P=0.51). For MS participants completing 60-min of exercise in WARM, ∆T_re (P=0.13), ∆T_sk (P=0.45), LSR_back (P=0.69) and LSR_arm (P=0.54) were similar to CON, but ΔT_b (MS:0.16±0.13˚C, CON:0.07±0.06˚C; P=0.02) and onset time (MS:16±10 min, CON:8±5 min; P=0.02) for sweating were greater. Similarly, in HOT, ∆T_re (P=0.52), ∆T_sk (P=0.06), LSR_back (P=0.59) and LSR_arm (P=0.08) were similar, but ΔT_b (MS: 0.19±0.16˚C, CON: 0.06±0.04˚C; P=0.04) and onset time (MS:13±7 min, CON:6±3 min; P=0.02) for sweating were greater with MS. Conclusion: Even at 35˚C, a delayed sweating onset didn't alter heat loss to sufficiently affect exercise-induced rises in core temperature. Heat intolerance with MS does not seem attributable to thermoregulatory impairments.

中文翻译：

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出汗不畅不会改变多发性硬化症患者在高温下运动时核心温度的升高

目的：确定在进行热运动时，MS是否改变体温调节能力。方法：16名MS（EDSS：2.9±0.9； 47±8 y； 77.6±14.0 kg）和14名健康（CON）对照参与者（43±11 y； 78.6±17.0 kg）以4 W.kg的热量循环^-1在30°C，30％RH（WARM）下60分钟。在35°C，30％RH（HOT）下也锻炼了8个MS（EDSS：2.6±0.5; 44±8 y; 82.3±18.2 kg）和8 CON（44±12 y; 81.2±21.1 kg）的子集。直肠（T _re），平均皮肤（T _sk）温度以及上背部（LSR_背部）和前臂（LSR_手臂）的局部出汗率），进行了测量。结果：所有CON，但在WARM和HOT试验中，分别只有16名中的9名和8名MS中的7名分别完成了60分钟的运动。所有参与者MS无法完全行使ΔT停止_再0.2-0.5˚C之间。达到∆T _re为0.2˚C的时间相似（MS：28±15分钟，CON：32±18分钟； P = 0.51）。对于在WARM中完成60分钟运动的MS参与者，∆T _re（P = 0.13），∆T _sk（P = 0.45），LSR_背部（P = 0.69）和LSR_手臂（P = 0.54）与CON相似，但ΔT _b（MS：0.16±0.13˚C，CON：0.07±0.06C; P = 0.02）和起效时间（MS：16±10分钟，CON：8±5分钟; P = 0.02），用于出汗是更大。同样，在HOT中，∆T _re（P = 0.52），∆T_SK（P = 0.06），LSR_背面（P = 0.59）和LSR_臂（P = 0.08）是类似的，但ΔT _b（MS：0.19±0.16˚C，CON：0.06±0.04˚C; P = 0.04）和MS出汗的发作时间（MS：13±7分钟，CON：6±3分钟； P = 0.02）更长。结论：即使在35°C时，出汗的延迟也不会改变热量的流失，从而不会充分影响运动引起的核心温度的升高。MS的热耐受性似乎不归因于温度调节障碍。