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High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-12-10 , DOI: 10.1111/nmo.14040
Maura Corsetti 1, 2, 3 , Alexander Thys 1 , Alexander Harris 2, 3 , Giuseppe Pagliaro 1 , Eveline Deloose 1 , Ingrid Demedts 1 , Jan Tack 1
Affiliation  

Polyethylene glycol (PEG), bisacodyl, and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and prucalopride are expected to directly stimulate the colonic motility in humans in vivo. As no previous study has done this, the aim of the study was to investigate the effect of PEG, bisacodyl, and prucalopride as compared to placebo on colonic motility assessed by means of the high‐resolution manometry (HRM) in healthy subjects.

中文翻译:

高分辨率测压揭示聚乙二醇、比沙可啶和普鲁卡必利对健康受试者结肠运动的不同影响:一项具有潜在临床意义的急性、开放标签、随机、交叉、读者盲法研究

据报道,聚乙二醇 (PEG)、比沙可啶和普卡必利在治疗便秘患者方面比安慰剂更有效,但仍有约 50% 的患者对这些药物没有反应。预计只有比沙可啶和普鲁卡必利在体内直接刺激人体结肠运动。由于之前没有研究这样做过,因此本研究的目的是研究 PEG、比沙可啶和普鲁卡必利与安慰剂相比对健康受试者通过高分辨率测压法 (HRM) 评估的结肠运动的影响。
更新日期:2020-12-10
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