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Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications
Macromolecular Materials and Engineering ( IF 3.9 ) Pub Date : 2020-12-09 , DOI: 10.1002/mame.202000593
Jian Zhang 1 , Yulin Wang 1 , Qingli Qu 1 , Tao Lu 1 , Fanghua Li 1 , Jing Wang 2 , Anquan Yang 2 , Yan Zou 3 , Chaobo Huang 1
Affiliation  

Microspheres applied in medical applications experience explosive development in recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both in economy and technology lay that cannot be ignored. For instance, microsphere technology has not been used in cell culture widely because of its uneconomical cost; as the core of drug‐loaded microsphere, targeted microsphere technology is still not mature enough. Besides, the common microsphere fabrication methods: microfluidic or emulsion technology is difficult to guarantee high biocompatibility of microsphere due to utilization of photoinitiator, crosslinking agent, surfactant, and other substances. Therefore, gas‐shearing technology has been proposed to solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than on single microspheres which begins with a minute introduction of microsphere preparation methods: microfluidic, coaxial electrospray, emulsion, and gas‐shearing technology. Then its medical applications: drug release, cell culture, bone tissue engineering, and hemostasis are discussed in detail. The disadvantages of fabrication methods and bottlenecks for medical applications at present are also stated. At the end, perspectives of microsphere development are put forward.

中文翻译:

异形微球的制备及其医学应用进展

近年来,用于医疗应用的微球体经历了爆炸性的发展,例如药物释放,细胞培养和骨组织工程等。然而,在经济和技术层面仍然存在一些不容忽视的瓶颈。例如,微球技术由于其不经济的成本而尚未广泛用于细胞培养中。作为载药微球的核心,靶向微球技术仍然不够成熟。此外,常见的微球制备方法:由于利用了光引发剂,交联剂,表面活性剂和其他物质,微流体或乳液技术难以保证微球的高生物相容性。因此,已经提出了气剪技术来成功解决上述缺点。本文将重点更多地放在异形微球上,而不是单个微球上,它首先介绍了微球的制备方法:微流体,同轴电喷雾,乳化和气体剪切技术。然后详细讨论其医学应用:药物释放,细胞培养,骨组织工程和止血。还陈述了目前用于医疗应用的制造方法和瓶颈的缺点。最后提出了微球发展的观点。和止血进行了详细讨论。还陈述了目前用于医疗应用的制造方法和瓶颈的缺点。最后提出了微球发展的观点。和止血进行了详细讨论。还陈述了目前用于医疗应用的制造方法和瓶颈的缺点。最后提出了微球发展的观点。
更新日期:2021-02-15
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