In this study, we investigate the potential protective effect of Moringa oleifera Lam. extract (MOE) against lead‐induced neurotoxicity. Wistar rats were allocated equally into (a) a control group, (b) a lead acetate (PbAc) group intraperitoneally injected with 20 mg/kg PbAc, (c) a MOE group orally gavaged with MOE (250 mg/kg), and (d) a MOE + PbAc group orally gavaged with MOE 3 hr before receiving intraperitoneal injections of PbAc. All rats were treated for 14 days. Our results revealed that PbAc‐induced brain injury, accompanied by increased levels of oxidative stress markers. Moreover, Pb enhanced the inflammatory response and triggered neuronal apoptosis, as well as significantly depleted glutathione content and inhibited antioxidant enzyme activity. Interestingly, concurrent treatment with MOE ameliorated oxidative stress, inflammation, and apoptosis in the brain cortex. The current study provides evidence that MOE has the potential to protect neuronal tissues in PbAc‐exposed rats via attenuation of nuclear factor‐kappa B (NF‐κB) signaling.

中文翻译：

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辣木林。提取物可拯救铅诱导的大鼠大脑皮层的氧化应激，炎症和细胞凋亡

在这项研究中，我们调查辣木的潜在保护作用我是。提取物（MOE）对抗铅诱导的神经毒性。将Wistar大鼠平均分为（a）对照组，（b）腹腔内注射20 mg / kg PbAc的乙酸铅（PbAc）组，（c）口服MOE（250 mg / kg）的MOE组和（d）在接受腹膜内注射PbAc之前3小时，MOE + PbAc组口服MOE。所有大鼠均治疗14天。我们的研究结果表明，PbAc诱发的脑损伤伴随着氧化应激标志物水平的升高。此外，Pb增强了炎症反应并触发了神经元凋亡，并显着耗尽了谷胱甘肽含量并抑制了抗氧化酶的活性。有趣的是，同时接受MOE治疗可减轻大脑皮质的氧化应激，炎症和细胞凋亡。