Despite performing certain morphological assessments for selecting the best embryo for transfer, the results have not been satisfactory. Given the global tendency for performing quick and noninvasive tests for embryo selection, great efforts have been made to discover the predictive biomarkers of embryo implantation potential. In recent years, many factors have been detected in embryo culture media as a major source of embryo secretions. Previous studies have evaluated cytokines, miRNAs, extracellular vesicles, and other factors such as leukemia inhibitory factor, colony‐stimulating factor, reactive oxygen species, soluble human leukocyte antigen G, amino acids, and apolipoproteins in these media. Given the key role of cytokines in embryo implantation, these factors can be considered promising molecules for predicting the implantation success of assisted reproductive technology (ART). The present study was conducted to review embryo‐secreted molecules as potential biomarkers for embryo selection in ART.

中文翻译：

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胚胎分泌组中的细胞因子作为胚胎选择的潜在标记

尽管进行了某些形态学评估以选择最佳胚胎进行移植，但结果并不令人满意。鉴于对胚胎选择进行快速和无创测试的全球趋势，已经做出了巨大努力来发现胚胎着床潜力的预测性生物标志物。近年来，许多因素在胚胎培养基中被发现是胚胎分泌物的主要来源。先前的研究已经评估了这些培养基中的细胞因子、miRNA、细胞外囊泡和其他因素，如白血病抑制因子、集落刺激因子、活性氧、可溶性人类白细胞抗原 G、氨基酸和载脂蛋白。鉴于细胞因子在胚胎植入中的关键作用，这些因素可以被认为是预测辅助生殖技术 (ART) 植入成功的有希望的分子。本研究旨在审查胚胎分泌分子作为 ART 胚胎选择的潜在生物标志物。