Objective

To summarize the recent evidence of traditional Chinese medicine (TCM) for food allergy and eczema.

Data Sources

Published literature from PubMed database and abstract conference presentations.

Study Selections

Studies relevant to TCM for food allergy and eczema were included.

Results

TCM is the main component of complementary and alternative medicine in the United States. Food Allergy Herbal Formula 2 (FAHF-2) (derived from the classical formula Wu Mei Wan) prevented systemic anaphylaxis in murine models and was found to have safety and preliminary immunomodulatory effects on T cells and basophils. The phase II trial of combined TCM with oral immunotherapy and omalizumab for multiple food allergy is ongoing. Retrospective practice-based evidence study revealed that comprehensive TCM therapy effectively prevented frequent and severe food anaphylaxis triggered by skin contact or protein inhalation. The traditional Japanese herbal medicine Kakkonto suppressed allergic diarrhea and decreased mast cells in intestinal mucosa in a murine model. The active compounds from TCM were found to have potent inhibition of immunoglobulin (Ig) E, mast cell activation, and proinflammatory cytokine or signaling pathway (tumor necrosis factor alpha, interleukin 8, NF-κB) suggesting value for both IgE and non–IgE-mediated food allergy. Triple TCM therapy including ingestion, bath, and cream markedly improved skin lesion, itching, and sleep loss in patients with corticosteroid dependent, recalcitrant, or topical steroid withdrawal. Xiao Feng San and Japanese and Korean formulas were found to have effectiveness in eczema. Furthermore, acupuncture reduced wheal size, skin itching, and basophil activation in atopic dermatitis. Moreover, TCM is generally safe.

Conclusion

TCM has potential as safe and effective therapy for food allergy and eczema. Further research is needed for botanical drug development and to further define the mechanisms of actions.

Trial Registration

FAHF-2: https://ichgcp.net/clinical-trials-registry/NCT00602160; ethyl acetate and butanol purified FAHF-2: https://clinicaltrials.gov/ct2/show/NCT02879006.

中文翻译：

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治疗食物过敏和湿疹的中药

客观的

总结中医药治疗食物过敏和湿疹的最新证据。

数据源

来自 PubMed 数据库的已发表文献和会议摘要。

研究选择

包括与中医治疗食物过敏和湿疹相关的研究。

结果

中医是美国补充和替代医学的主要组成部分。食物过敏草本配方 2 (FAHF-2)（源自经典配方五味丸）可预防小鼠模型中的全身性过敏反应，并被发现对 T 细胞和嗜碱性粒细胞具有安全性和初步免疫调节作用。中医药联合口服免疫疗法和奥马珠单抗治疗多种食物过敏的 II 期试验正在进行中。基于回顾性实践的证据研究表明，综合中医疗法可有效预防由皮肤接触或蛋白质吸入引发的频繁和严重的食物过敏反应。传统的日本草药 Kakkonto 在小鼠模型中抑制过敏性腹泻并减少肠粘膜中的肥大细胞。发现来自中药的活性化合物对免疫球蛋白 (Ig) E、肥大细胞活化和促炎细胞因子或信号通路（肿瘤坏死因子 α、白细胞介素 8、NF-κB）具有有效抑制作用，表明 IgE 和非 IgE 都具有价值-介导的食物过敏。包括摄入、沐浴和乳膏在内的三联中医疗法显着改善了皮质类固醇依赖性、顽固性或局部类固醇戒断患者的皮肤病变、瘙痒和睡眠不足。发现消风散和日韩方方对湿疹有效。此外，针灸减少了特应性皮炎中的风团大小、皮肤瘙痒和嗜碱性粒细胞活化。此外，中医通常是安全的。NF-κB) 表明对 IgE 和非 IgE 介导的食物过敏都有价值。包括摄入、沐浴和乳膏在内的三联中医疗法显着改善了皮质类固醇依赖性、顽固性或局部类固醇戒断患者的皮肤病变、瘙痒和睡眠不足。发现消风散和日韩方方对湿疹有效。此外，针灸减少了特应性皮炎中的风团大小、皮肤瘙痒和嗜碱性粒细胞活化。此外，中医通常是安全的。NF-κB) 表明对 IgE 和非 IgE 介导的食物过敏都有价值。包括摄入、沐浴和乳膏在内的三联中医疗法显着改善了皮质类固醇依赖性、顽固性或局部类固醇戒断患者的皮肤病变、瘙痒和睡眠不足。发现消风散和日韩方方对湿疹有效。此外，针灸减少了特应性皮炎中的风团大小、皮肤瘙痒和嗜碱性粒细胞活化。此外，中医通常是安全的。针灸减少了特应性皮炎中的风团大小、皮肤瘙痒和嗜碱性粒细胞活化。此外，中医通常是安全的。针灸减少了特应性皮炎中的风团大小、皮肤瘙痒和嗜碱性粒细胞活化。此外，中医通常是安全的。

结论

中医药具有安全有效的治疗食物过敏和湿疹的潜力。需要进一步研究植物药开发并进一步确定作用机制。

试用注册

FAHF-2：https://ichgcp.net/clinical-trials-registry/NCT00602160；乙酸乙酯和丁醇纯化的 FAHF-2：https://clinicaltrials.gov/ct2/show/NCT02879006。