Immunoglobulin A nephropathy (IgAN) is a common primary glomerular disease contributing to end-stage renal failure. In this study, the induced pluripotent stem cell line GWCMCi001-A from PBMCs of a 4-year-old male patient with IgAN using the episomal plasmids was established, which is an ideal in vitro model to understand the exact pathogenesis of IgAN.

中文翻译：

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四岁男性免疫球蛋白A肾病患者的PBMC诱导多能干细胞系（GWCMCi001-A）的衍生

免疫球蛋白A肾病（IgAN）是导致终末期肾衰竭的常见原发性肾小球疾病。在这项研究中，建立了使用游离质粒从4岁男性IgAN患者的PBMC诱导的多能干细胞系GWCMCi001-A，这是了解IgAN确切发病机理的理想体外模型。