Using the voltage-clamp technique, it has been shown for the first time that the neuroleptic drugs chlorpromazine and trifluoperazine, which act as sigma-1 receptor antagonists, attenuate Na⁺ transport in the frog skin epithelium. The results suggest that sigma-1 receptors may be involved in the regulation of transepithelial Na⁺ transport in frog skin.

中文翻译：

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Sigma-1受体配体氯丙嗪和三氟拉嗪抑制青蛙皮肤上皮细胞中的Na +转运。

使用电压钳技术，首次证明，作为sigma-1受体拮抗剂的抗精神病药氯丙嗪和三氟拉嗪可减弱青蛙皮肤上皮中的Na ⁺转运。结果表明，sigma-1受体可能参与了蛙皮中跨上皮Na ⁺转运的调节。