The pre- and postsynaptic effects of ATP on thermal sensibility in the diaphragm of the rat have been studied. It has been found that reduction in the bath temperatute from 37 to 22°С provokes a decrease in contractile force of diaphragm caused both by electrical stimulation and carbachol. At 37°C adding ATP to the incubation medium increases contractive activity of the diaphragm caused both by electrical stimulation and carbachol. These effects of ATP persist at lower temperatures, but are more prominent in carbachol-induced contractions. It is assumed that the thermosensitive component of purine modulation is located mostly postsynaptically in the diaphragm of the rat.

中文翻译：

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低温对大鼠膈肌嘌呤能突触调节的影响

已经研究了 ATP 对大鼠隔膜热敏感性的突触前和突触后影响。已经发现，将浴温从 37°C 降低到 22°C 会引起由电刺激和卡巴胆碱引起的隔膜收缩力的降低。在 37°C 下，向培养介质中添加 ATP 会增加由电刺激和卡巴胆碱引起的隔膜收缩活动。ATP 的这些影响在较低温度下持续存在，但在碳酰胆碱诱导的收缩中更为突出。假设嘌呤调制的热敏成分主要位于大鼠的隔膜中的突触后。