This work presents a highly sensitive biosensor based on a microcantilever and alternating current (AC) electrothermal technology. The AC electrothermal unit was developed and integrated with the cantilever chip to improve the capture efficiency of the molecules under test. The AC electrothermal effect enhanced the aggregation of molecules around the microcantilever, increased their binding probability to the sensor and improved the detection performance of the biosensor. This microcantilever sensor was used to detect Vibrio parahaemolyticus and achieved a detection limit of ∼5 10⁵ CFU ml⁻¹, one order of magnitude lower than that of the sensor without AC electrothermal technology. Meanwhile, the detection time was reduced to 40 min, nearly half that of the conventional cantilever sensors.

这项工作提出了一种基于微悬臂和交流电（AC）电热技术的高灵敏度生物传感器。开发了交流电热单元并与悬臂芯片集成在一起，以提高被测分子的捕获效率。交流电热效应增强了微悬臂梁周围分子的聚集，增加了它们与传感器的结合概率，并改善了生物传感器的检测性能。该微悬臂梁传感器用于检测副溶血性弧菌，检出限约为⁵ 10 ⁵ CFU ml ^-1，比没有交流电热技术的传感器低一个数量级。同时，检测时间减少到40分钟，几乎是传统悬臂传感器的一半。