Mitochondria are dynamic organelles adapting their morphology by cycles of fission and fusion events to control cellular homeostasis. In this issue of The EMBO Journal, Murata and colleagues (2020) show that lack of mitochondrial division leads to safeguard mechanisms, induced by transient mitochondrial membrane depolarization and activation of the metalloprotease OMA1, to prevent extreme mitochondrial fusion and to maintain optimal mitochondrial bioenergetics.

中文翻译：

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防止极端和有害的线粒体融合的最后一道防线

线粒体是动态细胞器，通过裂变和融合事件的循环来调整其形态以控制细胞稳态。在本期The EMBO Journal中，Murata 及其同事 (2020) 表明，线粒体分裂的缺乏会导致由瞬时线粒体膜去极化和金属蛋白酶 OMA1 激活诱导的保护机制，以防止极端线粒体融合并维持最佳的线粒体生物能量学。