The results of mass spectrometric studies of surface ionization of molecules of psychotropic drugs such as chlorpromazine, amitriptyline and medazepam in an air atmosphere have been presented. The channels of heterogeneous reactions occurring during the molecule adsorption on the hot surface of the thermoemitter from refractory metal oxides have been revealed, as well as the influence of air atmosphere on these reactions. A strong influence of the air atmosphere on the heterogeneous association reactions with the emission of [M + H]+ ions has been found. This ion line is the main in the mass spectra of all the substances under study instead of the characteristic main line in the surface ionization mass spectra obtained in vacuum. The effect of air on the reactions of dehydrogenation and dissociation of adsorbed molecules of organic compounds has been insignificant. In the surface ionization mass spectra of all the substances studied under atmospheric conditions the adduct cluster ions М⋅[М−R]+, М⋅[М−Н]+ and М⋅[М+Н]+ (where М is the molecule, R is the radical, H is the hydrogen atom) up to М⋅[М+Н]+⋅HCl. They are probably formed by adhesion of analyte molecules to the primary ions [М−R]+, [М−Н]+ and [М+Н]+. A comparative analysis has been also performed with the data obtained by chromato-mass spectrometry with electron ionization, as well as with the surface ionization data for these preparations obtained under high vacuum.

中文翻译：

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空气气氛对精神药物分子表面电离作用下异质反应的影响

已经介绍了精神药物分子（如氯丙嗪、阿米替林和美西泮）在空气中的表面电离质谱研究结果。已经揭示了分子在难熔金属氧化物的热发射体热表面吸附过程中发生的多相反应通道，以及空气气氛对这些反应的影响。已经发现大气对具有 [M + H]+ 离子发射的异质缔合反应有很强的影响。这条离子线是所有被研究物质的质谱中的主线，而不是真空中获得的表面电离质谱中的特征主线。空气对吸附的有机化合物分子的脱氢和解离反应的影响是微不足道的。在大气条件下研究的所有物质的表面电离质谱中，加合物簇离子 М⋅[М-R]+、М⋅[М-Н]+ 和 М⋅[М+Н]+（其中 М 是分子, R 是自由基，H 是氢原子）直到 М⋅[М+Н]+⋅HCl。它们可能是由分析物分子与主要离子 [М-R]+、[М-Н]+ 和 [М+Н]+ 的粘附形成的。还对通过电子电离的色谱质谱法获得的数据以及在高真空下获得的这些制剂的表面电离数据进行了比较分析。М⋅[М−Н]+ 和 М⋅[М+Н]+（其中 М 是分子，R 是自由基，H 是氢原子）直到 М⋅[М+Н]+⋅HCl。它们可能是由分析物分子与主要离子 [М-R]+、[М-Н]+ 和 [М+Н]+ 的粘附形成的。还对通过电子电离的色谱质谱法获得的数据以及在高真空下获得的这些制剂的表面电离数据进行了比较分析。М⋅[М−Н]+ 和 М⋅[М+Н]+（其中 М 是分子，R 是自由基，H 是氢原子）直到 М⋅[М+Н]+⋅HCl。它们可能是由分析物分子与主要离子 [М-R]+、[М-Н]+ 和 [М+Н]+ 的粘附形成的。还对通过电子电离的色谱质谱法获得的数据以及在高真空下获得的这些制剂的表面电离数据进行了比较分析。