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Primary sinonasal malignant melanoma with systemic metastasis in a non-gray horse
The Journal of Veterinary Diagnostic Investigation ( IF 1.5 ) Pub Date : 2020-12-08 , DOI: 10.1177/1040638720978561
Hitoshi Hatai 1 , Takashi Hatazoe 2 , Haruka Seo 1 , Teruaki Tozaki 3 , Shingo Ishikawa 2 , Noriaki Miyoshi 1 , Kazuhiro Misumi 2 , Seiji Hobo 2
Affiliation  

A 27-y-old Anglo-Arabian gelding with bay coat color was presented with a swelling of the left maxillary region. Fenestration on the left maxilla revealed that the left maxillary sinus was filled with black-red tissue. A portion of the tissue was excised and diagnosed histologically as malignant melanoma. Genotyping of the STX17 gene for gray coat color revealed that the horse did not have the “gray” factor. The horse was euthanized ~3 mo after first presentation. During autopsy, a black-to-gray mass extended from the left nasal cavity to the surrounding paranasal sinus and invaded the hard palate, cribriform plate, and the cranial portion of the left olfactory bulb. Moreover, identical black nodules were present in lymph nodes from the mandible to the larynx, and in the spleen, liver, kidney, and adrenal glands. However, masses were not found in the skin, perineal region, or pelvic cavity. All of the black-to-gray nodules were malignant melanomas that were histologically identical to the initial biopsy; tumor emboli were also found in the kidney. Sinonasal mucosal melanoma is a rare disease in horses.



中文翻译:

非灰马全身转移的原发性鼻窦恶性黑色素瘤

一只 27 岁的盎格鲁-阿拉伯马驹被毛颜色为月桂色,左上颌区域肿胀。左上颌开窗显示左上颌窦充满黑红色组织。部分组织被切除并在组织学上被诊断为恶性黑色素瘤。STX17 的基因分型灰色毛色基因表明这匹马没有“灰色”因素。这匹马在第一次出现后约 3 个月被安乐死。在尸检过程中,黑色至灰色的肿块从左侧鼻腔延伸至周围的鼻旁窦,并侵入硬腭、筛板和左侧嗅球的颅骨部分。此外,从下颌骨到喉部的淋巴结以及脾脏、肝脏、肾脏和肾上腺中都存在相同的黑色结节。然而,在皮肤、会阴区或盆腔中未发现肿块。所有黑色到灰色的结节都是恶性黑色素瘤,在组织学上与最初的活检结果相同;在肾脏中也发现了肿瘤栓子。鼻腔黏膜黑色素瘤是马的一种罕见疾病。

更新日期:2020-12-09
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