BACKGROUND To demonstrate an inflammatory process in the central nervous system, the presence of at least two immunoglobulin (Ig) bands in the cerebrospinal fluid (CSF) is required. So far, the presence of a single abnormal Ig band is considered as negative. OBJECTIVE The objective was to assess retrospectively the significance of a single CSF Ig band in clinical practice. METHODS AND RESULTS Out of 10,286 CSF analyses, we retained 214 results with single Ig. An inflammatory neurological disorder was diagnosed in 41% of patients. CONCLUSION Despite a modest sensitivity, the presence of a single CSF Ig band may be a biomarker of an inflammatory mechanism and, as such, may prompt the clinician to repeat the analysis when the clinical context remains suggestive.

中文翻译：

---

脑脊液免疫球蛋白单条带临床意义的回顾性研究

背景 为了证明中枢神经系统中的炎症过程，需要脑脊液 (CSF) 中存在至少两个免疫球蛋白 (Ig) 带。到目前为止，单个异常 Ig 带的存在被认为是阴性的。目的 目的是回顾性评估单个 CSF Ig 带在临床实践中的重要性。方法和结果 在 10,286 次 CSF 分析中，我们保留了 214 次使用单一 Ig 的结果。41% 的患者被诊断为炎性神经系统疾病。结论 尽管敏感性适中，但单个 CSF Ig 条带的存在可能是炎症机制的生物标志物，因此，当临床背景仍然具有暗示性时，可能会促使临床医生重复分析。