Many natural products possess interesting medicinal properties that arise from their intriguing chemical structures. The highly-substituted carbocycle is one of the most common structural features in many structurally complicated natural products. However, the construction of highly-substituted, stereo-congested, five-membered carbocycles containing all-carbon quaternary center(s) is, at present, a distinct challenge in modern synthetic chemistry, which can be accessed through the all-carbon [3 + 2] cycloaddition. More importantly, the all-carbon [3 + 2] cycloaddition can forge vicinal all-carbon quaternary centers in a single step and has been demonstrated in the synthesis of complex natural products. In this review, we present the development of all-carbon [3 + 2] cycloadditions and illustrate their application in natural product synthesis reported in the last decade covering 2011–2020 (inclusive).

中文翻译：

---

天然产物合成中的全碳[3 + 2]环加成

许多天然产物都具有有趣的医学特性，这些特性来自其有趣的化学结构。在许多结构复杂的天然产物中，高度取代的碳环是最常见的结构特征之一。然而，目前构建包含全碳四元中心的高度取代的，立体拥挤的五元碳环是现代合成化学中的一个独特挑战，可以通过全碳[3]来获得。 + 2]环加成。更重要的是，全碳[3 + 2]环加成反应可一步形成伪造的全碳四元中心，并且在合成复杂的天然产物中得到了证明。在这篇评论中