Depolarization of circularly polarized light scattered from biological tissues depends on structural changes in cell nuclei, which can provide valuable information for differentiating cancer tissues concealed in healthy tissues. In this study, we experimentally verified the possibility of cancer identification using scattering of circularly polarized light. We investigated the polarization of light scattered from a sliced biological tissue with various optical configurations. A significant difference between circular polarizations of light scattered from cancerous and healthy tissues is observed, which is sufficient to distinguish a cancerous region. The line‐scanning experiments along a region incorporating healthy and cancerous parts indicate step‐like behaviors in the degree of circular polarization corresponding to the state of tissues, whether cancerous or normal. An oblique and perpendicular incidence induces different resolutions for identifying cancerous tissues, which indicates that the optical arrangement can be selected according to the priority of resolution.

中文翻译：

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圆偏振光用于癌症识别的角度优化

从生物组织散射的圆偏振光的去极化取决于细胞核的结构变化，这可以为区分健康组织中隐藏的癌组织提供有价值的信息。在这项研究中，我们通过圆偏振光的散射实验验证了癌症鉴定的可能性。我们研究了从具有各种光学配置的切片生物组织散射的光的偏振。观察到从癌组织和健康组织散射的光的圆偏振之间的显着差异，这足以区分癌区域。沿着包含健康和癌变部位的区域进行的线扫描实验表明，圆极化程度的阶梯状行为与组织状态相对应，无论是癌变还是正常。倾斜和垂直入射会产生不同的分辨率来识别癌变组织，这表明可以根据分辨率的优先级选择光学装置。