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SYNTHESIS AND CHARACTERIZATION OF SUBSTRATES FOR GRAFTING POLYMERS USED IN MEDICAL PLASTICS
Chemical Data Collections Pub Date : 2021-02-01 , DOI: 10.1016/j.cdc.2020.100621
Meghan R. Johnston , Hany F. Sobhi , Alaa El Hajjar

ABSTRACT This synthetic overview describes the formation and characterization of branched substrates for future use in obtaining graft copolymers with characteristics appropriate for medical plastics. Due to the critical necessity of medical devices, optimization of materials used in their production is of substantial interest. The substrate synthesis was varied by utilizing reactants with different heteroatoms (e.g., diols, dithiols) and chain lengths. Although sixteen new molecules were synthesized and confirmed by high resolution mass spectrometry (HRMS), the reaction conditions and purification methodology require further optimization before subsequent use. The objective of this research was to synthesize novel substrates for altering the physical properties of polymers used for clinical applications. Experimental results and crude spectral data analysis are provided herein for newly synthesized compounds.

中文翻译:

医用塑料接枝聚合物基材的合成和表征

摘要 该合成概述描述了支化底物的形成和表征,以备将来用于获得具有适合医用塑料特性的接枝共聚物。由于医疗器械的必要性,因此对其生产中使用的材料进行优化具有重大意义。通过使用具有不同杂原子(例如二醇、二硫醇)和链长的反应物来改变底物合成。尽管合成了 16 个新分子并通过高分辨率质谱 (HRMS) 进行了确认,但反应条件和纯化方法在后续使用之前需要进一步优化。这项研究的目的是合成新的底物,以改变用于临床应用的聚合物的物理特性。
更新日期:2021-02-01
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