Background

The age-related muscle mass loss has been associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). In healthy individuals, pulse pressure (PP) is lower in the aorta compared to the brachial artery (PP amplification, PPA). Postmenopausal women experience elevated aortic stiffness leading to increased AIx and aortic PP causing reduced PPA, an independent predictor of cardiovascular mortality. It is unknown whether appendicular skeletal muscle index (ASMI), arm (ArmLM) or leg lean mass (LegLM) are negatively associated with PPA. The purpose of this study was to investigate the associations between vascular function (PPA, AIx, and baPWV) and lean mass (ASMI, ArmLM, and LegLM) in postmenopausal women.

Methods

The study was performed in 93 postmenopausal women (48–71 years; BMI: 30 ± 7 kg/m²). PPA (brachial/aortic PP), aortic AIx, and baPWV were measured. ArmLM and LegLM were measured by dual-energy X-ray absorptiometry. ASMI was calculated as (ArmLM+LegLM)/Ht². Associations between vascular and lean mass measures were analyzed by multiple linear regression.

Results

PPA was associated with ASMI (β = 0.29, p = .016) and LegLM (β = 0.25, p = .028) after adjustment for age, height, systolic pressure, strength, and heart rate. AIx was associated with ASMI (β = −0.27, p = .011), ArmLM (β = −0.25, p = .023), and LegLM (β = −0.22, p = .026), while baPWV was associated with reduced ASMI (β = −0.23, p = .043) and ArmLM (β = −0.23, p = .045), but not with LegLM (β = −0.19, p = .074) after full adjustment.

Conclusions

Our findings indicate that impaired pulsatile hemodynamics (PPA and AIx) are negatively associated with ASMI and LegLM, while arterial stiffness is negatively associated with ASMI and ArmLM. Thus, vascular dysfunction may be implicated in muscle mass loss in overweight and obese postmenopausal women.

中文翻译：

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超重和肥胖的绝经后女性的脉压扩增，增强指数和动脉僵硬度受损与肢体瘦体重减少有关

背景

与年龄有关的肌肉质量损失与动脉僵硬度（肱-踝脉搏波速度，baPWV）和波反射（增强指数，AIx）相关。在健康个体中，与肱动脉相比，主动脉中的脉压（PP）较低（PP放大，PPA）。绝经后妇女的主动脉僵硬度升高，导致AIx升高，主动脉PP升高，PPA降低，PPA是心血管疾病死亡率的独立预测指标。尚不清楚阑尾骨骼肌指数（ASMI），手臂（ArmLM）或小腿瘦体重（LegLM）是否与PPA负相关。这项研究的目的是调查绝经后妇女的血管功能（PPA，AIx和baPWV）与瘦体重（ASMI，ArmLM和LegLM）之间的关联。

方法

这项研究是针对93名绝经后女性（48-71岁； BMI：30±7 kg / m ²）进行的。测量了PPA（肱/主动脉PP），主动脉AIx和baPWV。ArmLM和LegLM通过双能X射线吸收法测量。ASMI计算为（ArmLM + LegLM）/ Ht ²。通过多元线性回归分析血管和瘦体重测量之间的关联。

结果

 在调整了年龄，身高，收缩压，力量和心率之后，PPA与ASMI（β  = 0.29，p = .016）和LegLM（β = 0.25，p = .028）相关。AIx与ASMI（β  = -0.27，p = .011），ArmLM（β  = -0.25，p = .023）和LegLM（β  = -0.22，p = .026）相关，而baPWV与降低相关ASMI（β  = -0.23，p = .043）和ArmLM（β  = -0.23，p = .045），但 在完全调整后不使用LegLM（β = -0.19，p = .074）。

结论

我们的发现表明，脉动性血流动力学受损（PPA和AIx）与ASMI和LegLM负相关，而动脉僵硬度与ASMI和ArmLM负相关。因此，在超重和肥胖的绝经后妇女中，血管功能障碍可能与肌肉质量下降有关。