Cutaneous treatment possesses advantages, including the decrease of transient drug overdosage or systematic side effects. The evolution of biomedical materials with multifunctionalities to overcome the limitations of existing materials can bring revolutionary development in this field. A promising solution can turn to the emerging materials known as metal-organic frameworks (MOFs), featuring high porosity, easy modification, and multifunctionality. The work herein developed a systemic assay package to seek suitable MOFs for cutaneous applications. Versatile platforms based on MOFs were built, which integrated superb functions and features, including biocompatibilities, sebum adsorbability, selective adsorption, antimicrobial activity, controlled release, and skin permeability promotion. Such features endow MOFs as high-performance matrixes for cutaneous applications. This study paves a new avenue for the reformation of cosmetic and biomedicinal materials. Moreover, this comprehensive MOF screening system can be broadly applied for material evaluation in this field, which also provides valuable guidance for the design of advanced biomedical materials.

皮肤治疗具有优势，包括减少短暂的药物过量或系统的副作用。为了克服现有材料的局限性，具有多功能的生物医学材料的发展可以带来这一领域的革命性发展。一种有前途的解决方案可以转向新兴的被称为金属有机骨架（MOF）的材料，该材料具有高孔隙率，易于修饰和多功能的特点。本文的工作开发了一种全身化验试剂盒，以寻求适合皮肤应用的MOF。建立了基于MOF的多功能平台，该平台整合了出色的功能和特征，包括生物相容性，皮脂吸附性，选择性吸附，抗菌活性，控释和促进皮肤渗透性。这些特征使MOF成为用于皮肤应用的高性能基质。这项研究为化妆品和生物医学材料的改革开辟了一条新途径。而且，这种全面的MOF筛选系统可广泛应用于该领域的材料评估，这也为先进生物医学材料的设计提供了宝贵的指导。