当前位置: X-MOL 学术EMBO Rep. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Antibiotic resistance and persistence—Implications for human health and treatment perspectives
EMBO Reports ( IF 7.7 ) Pub Date : 2020-12-08 , DOI: 10.15252/embr.202051034
Markus Huemer 1 , Srikanth Mairpady Shambat 1 , Silvio D Brugger 1 , Annelies S Zinkernagel 1
Affiliation  

Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of treatment failure and relapsing infections. They are thus important drivers of increased morbidity and mortality rates resulting in growing healthcare costs. Antibiotic resistance is readily identifiable with standard microbiological assays, and the threat imposed by antibiotic resistance has been well recognized. Measures aiming to reduce resistance development and spreading of resistant bacteria are being enforced. However, the phenomenon of bacteria surviving antibiotic exposure despite being fully susceptible, so‐called antibiotic persistence, is still largely underestimated. In contrast to antibiotic resistance, antibiotic persistence is difficult to measure and therefore often missed, potentially leading to treatment failures. In this review, we focus on bacterial mechanisms allowing evasion of antibiotic killing and discuss their implications on human health. We describe the relationship between antibiotic persistence and bacterial heterogeneity and discuss recent studies that link bacterial persistence and tolerance with the evolution of antibiotic resistance. Finally, we review persister detection methods, novel strategies aiming at eradicating bacterial persisters and the latest advances in the development of new antibiotics.

中文翻译:

抗生素耐药性和持久性——对人类健康和治疗的影响

抗菌素耐药性 (AMR) 和持久性与治疗失败和复发感染的风险升高有关。因此,它们是导致发病率和死亡率增加的重要驱动因素,从而导致医疗保健成本不断增加。抗生素耐药性很容易通过标准微生物检测来识别,并且抗生素耐药性带来的威胁已得到广泛认可。旨在减少耐药性发展和耐药性细菌传播的措施正在实施。然而,尽管细菌完全易感,但仍存在抗生素暴露的现象,即所谓的抗生素持久性,仍然在很大程度上被低估了。与抗生素耐药性相比,抗生素的持久性难以衡量,因此经常被遗漏,可能导致治疗失败。在本次审查中,我们专注于允许逃避抗生素杀伤的细菌机制,并讨论它们对人类健康的影响。我们描述了抗生素持久性和细菌异质性之间的关系,并讨论了最近将细菌持久性和耐受性与抗生素耐药性的演变联系起来的研究。最后,我们回顾了持久性检测方法、旨在根除细菌持久性的新策略以及新抗生素开发的最新进展。
更新日期:2020-12-10
down
wechat
bug