The effect of Schisandra chinensis extract (SCE) on the learning and memory ability of mice with learning and memory disorders was investigated. After mice were given SCE prophylactically, different methods were used to establish mouse learning and memory disorders, and the radial maze test was used for the observation of SCE on the learning and memory ability of mice with learning and memory disorders. A mouse aging model was established by subcutaneously injecting d-galactose. The antiaging, antifatigue, and antioxidant effects of SCE were evaluated by weight change, the loaded swimming test, and changes in total antioxidant capacity and superoxide dismutase (SOD) levels in the serum and brain of mice. The result showed that SCE could significantly improve the learning and memory behavior of mice with learning and memory disorders induced by scopolamine, chloramphenicol, and 40% ethanol, respectively, maintain normal weight gain, prolong the loaded swimming time, improve the antioxidant capacity, and increase the activity of SOD in the serum and brain of aging mice. SCE can significantly improve the learning and memory ability of mice with learning and memory disorders, which may be related to its antioxidant effect.

研究了五味子提取物（SCE）对学习记忆障碍小鼠学习记忆能力的影响。预防性给予小鼠SCE后，采用不同方法建立小鼠学习记忆障碍，并采用放射状迷宫实验观察SCE对学习记忆障碍小鼠的学习记忆能力。皮下注射d建立小鼠衰老模型。-半乳糖。SCE的抗衰老，抗疲劳和抗氧化作用通过体重变化，负荷游泳试验以及小鼠血清和大脑中总抗氧化能力和超氧化物歧化酶（SOD）水平的变化进行评估。结果表明，SCE可以显着改善东碱，氯霉素和40％乙醇分别诱发的具有学习和记忆障碍的小鼠的学习和记忆行为，维持正常的体重增加，延长负荷游泳时间，提高抗氧化能力以及增加衰老小鼠血清和脑中SOD的活性。SCE可以显着提高患有学习和记忆障碍的小鼠的学习和记忆能力，这可能与其抗氧化作用有关。