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Indoor-related microbe damage induces complement system activation in building users
Innate Immunity ( IF 3.2 ) Pub Date : 2020-12-07 , DOI: 10.1177/1753425920966641
Janne Atosuo 1, 2 , Outi Karhuvaara 1, 2 , Eetu Suominen 1, 2 , Liisa Vilén 2 , Jari Nuutila 1 , Tuula Putus 2
Affiliation  

In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli-lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant (P < 0.001) increase in activity was found in the classical reaction pathway. This study strengthens our notion that exposure to indoor-related microbe damage increases the risk for systemic subclinical inflammation and creates a health risk for building users.



中文翻译:

室内相关微生物损伤诱导建筑用户的补体系统激活

在这项比较研究中,从 159 个血清样本中测量了血清补体系统的抗菌活性,这些样本取自微生物受损(70 个样本)和参考建筑物(89 个样本)的个体。使用基于探针的细菌大肠杆菌-lux 生物发光系统评估抗菌活性,并在实验组和参考组之间的组水平上进行比较。与参考组相比,微生物破坏建筑使用者的补体活性更高,显着(P < 0.001) 在经典反应途径中发现活性增加。这项研究强化了我们的观点,即暴露于室内相关微生物损害会增加全身性亚临床炎症的风险,并给建筑用户带来健康风险。

更新日期:2020-12-08
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