This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer’s disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.

这项前瞻性队列研究“衰老的前瞻性影像研究：基因，大脑和行为”（PISA）旨在刻画健康的成年澳大利亚人的表型和自然病史，这些人的未来患阿尔茨海默氏病（AD）的风险较高。尤其是，我们正在招募痴呆症遗传风险高低的中年和年龄较大的澳大利亚人，以发现早期神经病理学的生物学标记，确定可改变的危险因素，并建立疾病发作的最早的表型和神经元体征。PISA利用遗传预测招募和丰富了预期的研究对象，并对其进行纵向跟踪。在线调查和认知测试被用来表征目前在澳大利亚范围内共有3800名参与者的样本。来自明确的高危人群和阳性对照（轻度认知障碍或早期AD的患者的临床队列）的参与者被邀请进行现场访问，以进行详细的功能，结构和分子神经影像学检查，生活方式监测，详细的神经认知测试以及献血。本文介绍了PISA队列的招募，研究方法和基线人口统计数据。