Photostable organic dyes are required for long‐time or super‐resolution bioimaging. In this work, an effective improvement of photostability of a coumarin dye (Pacific Blue (PB)) is demonstrated by steric protection using a cyclodextrin. The PB‐conjugated cyclodextrin (PB‐CD) showed suppression of photodegradation and reactive oxygen species (ROS) generation during photoirradiation as compared to PB. The effects afford an improvement of photostability of PB dye. Finally, the photostability of PB‐CD was evaluated using confocal laser scanning microscopy (CLSM) and a significant improved effect was proven even in living cells. More information can be found in the Communication by Hajime Shigemitsu, Toshiyuki Kida, et al.

中文翻译：

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封面功能：通过自掺入水溶液和活细胞中的环糊精腔中来增强香豆素染料的光稳定性（Asian J. Org。Chem。12/2020）

长期或超分辨率生物成像需要光稳定的有机染料。在这项工作中，通过使用环糊精进行空间保护，证明了香豆素染料（太平洋蓝（PB））的光稳定性的有效提高。所述PB缀合的环糊精（PB-CD）光照射时的光降解和活性氧物质（ROS）的生成的抑制表现出相比于PB。该效果提供了PB染料的光稳定性的改善。最后，PB‐CD的光稳定性使用共聚焦激光扫描显微镜（CLSM）进行了评估，即使在活细胞中也证明了明显的改善效果。有关更多信息，请参见Hajime Shigemitsu，Toshiyuki Kida等的《通讯》。